Skip to main content

Table 2 Dosimetric parameters of the organs at risk in the three radiotherapy techniques studied

From: Dosimetric rationale and preliminary experience in proton plus carbon-ion radiotherapy for esophageal carcinoma: a retrospective analysis

OARs

Characteristics

IMRT

IMPT

IMCT

p

(IMRT vs. IMPT

p

(IMRT vs. IMCT)

p

(IMPT vs. IMCT)

Spinal cord

Dmax (Gy)

48.5 ± 9.5

37.3 ± 7.4

34.3 ± 8.2

< 0.001

< 0.001

< 0.001

D1% (Gy)

43.8 ± 9.4

30.8 ± 7.7

28.3 ± 8.8

< 0.001

< 0.001

0.001

MBT

Dmax (Gy)

72.8 ± 1.1

71.4 ± 0.6

72.2 ± 0.9

< 0.001

0.048

0.001

D1% (Gy)

71.4 ± 0.8

69.6 ± 0.7

70.1 ± 1.3

< 0.001

< 0.001

0.017

Heart

Dmean (Gy)

14.7 ± 13.3

4.9 ± 4.2

5.8 ± 5.1

< 0.001

< 0.001

0.031

V5 (%)

44.7 ± 40.4

14.5 ± 11.3

20.2 ± 16.9

0.001

0.001

0.011

V10 (%)

40.3 ± 38.8

11.5 ± 9.3

12.8 ± 10.7

0.002

0.002

0.031

V20 (%)

30.1 ± 29.7

8.2 ± 7.0

8.7 ± 7.6

0.005

0.002

0.061

V30 (%)

23.6 ± 24.4

6.3 ± 5.6

6.6 ± 5.8

0.003

0.003

0.041

V40 (%)

12.5 ± 13.0

5.0 ± 4.7

5.1 ± 4.9

0.005

0.005

0.19

V50 (%)

6.3 ± 6.2

4.0 ± 4.1

4.1 ± 4.3

0.005

0.005

0.40

V60 (%)

4.5 ± 4.8

3.1 ± 3.4

3.2 ± 3.6

0.003

0.004

0.048

Lungs

Dmean (Gy)

12.4 ± 4.9

8.6 ± 3.4

8.9 ± 3.4

0.002

0.003

0.037

V5 (%)

46.1 ± 18.3

31.0 ± 11.4

32.2 ± 12.1

0.001

0.002

0.093

V10 (%)

37.3 ± 15.5

25.9 ± 9.8

25.9 ± 9.8

0.002

0.002

0.74

V20 (%)

28.0 ± 12.5

18.2 ± 7.7

19.0 ± 7.3

0.002

0.002

0.31

V30 (%)

15.1 ± 8.2

11.0 ± 6.1

13.3 ± 6.0

0.057

0.43

0.005

V40 (%)

5.4 ± 3.7

5.1 ± 2.8

6.0 ± 3.1

0.91

0.17

0.017

V50 (%)

2.8 ± 1.9

3.0 ± 1.7

3.0 ± 1.6

0.53

0.33

0.17

V60 (%)

1.8 ± 1.2

2.0 ± 1.3

2.0 ± 1.1

0.25

0.13

0.71

  1. Abbreviations: OARs, organs at risk; Dmax, maximum dose; D1%, the dose that 1% of the volume received of the OARs; Dmean, mean dose; Vx, the percentage volume of the organs at risk receiving ≥ x Gy irradiation; MBT, main bronchial tree; IMRT, intensity modulated x-ray radiotherapy; IMPT, intensity modulated proton radiotherapy; IMCT, intensity modulated carbon-ion radiotherapy. *Doses are presented as the RBE (relative biological effectiveness)-weighted dose