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Table 4 Subgroup analysis between the linear accelerator (LA)- and CyberKnife (CK)-based systems

From: Noninvasive cardiac radioablation for ventricular tachycardia: dosimetric comparison between linear accelerator- and robotic CyberKnife-based radiosurgery systems

 

PTV ≤ 50 cm3 (n = 7)

PTV > 50 cm3 (n = 6)

LA

CK

p-value†

LA

CK

p-value†

CI (ratio)

0.91 ± 0.02

0.90 ± 0.03

0.551

0.82 ± 0.08

0.77 ± 0.05

0.129

GI (ratio)

3.38 ± 0.46

2.78 ± 0.36

0.028

3.60 ± 0.66

3.52 ± 0.83

0.619

GM (cm)

0.93 ± 0.15

0.76 ± 0.13

0.007

1.45 ± 0.07

1.28 ± 0.10

 < 0.001

D2cm (%)

51.0 ± 5.8

42.9 ± 4.1

0.027

55.5 ± 3.8

59.9 ± 5.4

0.273

Treatment time estimates (min)

21.7 ± 1.8

120.2 ± 18.1

 < 0.001

23.2 ± 0.8

118.2 ± 37.4

0.002

 

Spherical PTV (n = 6)

Non-spherical PTV (n = 7)

LA

CK

p-value†

LA

CK

p-value†

CI (ratio)

0.91 ± 0.01

0.90 ± 0.04

0.515

0.83 ± 0.07

0.78 ± 0.06

0.139

GI (ratio)

3.35 ± 0.50

2.63 ± 0.23

0.029

3.59 ± 0.60

3.51 ± 0.76

0.531

GM (cm)

0.93 ± 0.17

0.73 ± 0.12

0.006

1.37 ± 0.21

1.22 ± 0.17

0.001

D2cm (%)

51.5 ± 6.2

42.9 ± 4.4

0.046

54.4 ± 4.4

57.5 ± 8.0

0.395

  1. Values are presented as the mean ± standard deviation
  2. CI conformity index, D2cm maximum dose 2 cm from the planning target volume in any direction, GI gradient index, GM gradient measure, PTV planning target volume
  3. †Significance is tested using the paired-sample t-test, with p < 0.05 indicating statistical significance