Fig. 6

Expression of plasma sEV miR-152-3p and KLF15, and its prognostic value. A The level of sEV miR-152-3p in CC patients with or without recurrence after radiotherapy was analyzed by qRT-PCR (n = 20 in each group), indicating increased sEV miR-152-3p was found in recurrent CC patients compared with non-recurrent CC patients. **P < 0.01 vs non-recurrence. B The expression of KLF15 in the above patients (n = 20 in each group) was shown by qRT-PCR verifies, indicating reduced sEV KLF15 was found in recurrent CC patients compared with non-recurrent CC patients. **P < 0.01 vs non-recurrence. C Correlation analysis between miR-152-3p and KLF15 in the same patients was performed qRT-PCR, the expression of KLF15 mRNA in CC tissues of these patients was negatively correlated with the level of plasma sEV miR-152-3p. **P < 0.01 vs non-recurrence. D Kaplan–Meier survival rate analysis of the overall survival rate of these patients by miR-152-3p expression level in tissues was analyzed by Kaplan–Meier analysis. **P < 0.01 vs non-recurrence