Fully automated volumetric modulated arc therapy technique for radiation therapy of locally advanced breast cancer

Marrazzo, Livia; Redapi, Laura; Pellegrini, Roberto; Voet, Peter; Meattini, Icro; Arilli, Chiara; Calusi, Silvia; Casati, Marta; Chilà, Deborah; Compagnucci, Antonella; Talamonti, Cinzia; Zani, Margherita; Livi, Lorenzo; Pallotta, Stefania

doi:10.1186/s13014-023-02364-8

Table 2 Plan parameters for manually generated Tomotherapy plans (HT) and automatically generated VMAT plans (AP-VMAT).

From: Fully automated volumetric modulated arc therapy technique for radiation therapy of locally advanced breast cancer

	parameter		mean value ± 1 SD	range	p-value
PTV breast/CW	V_95% [%]	HT	97 ± 2	90–100	0.7
	V_95% [%]	AP-VMAT	97 ± 1	95–100	0.7
	D_1% [Gy]	HT	52.1 ± 0.6	51.1–53.2	0.01
	D_1% [Gy]	AP-VMAT	52.9 ± 0.4	51.5–53.4	0.01
	V_105% [%]	HT	0.7 ± 0.8	0.02–2.48	0.003
	V_105% [%]	AP-VMAT	5.6 ± 2.7	0.1–13.2	0.003
PTV III-IV	V_95% [%]	HT	97 ± 2	79–100	0.2
	V_95% [%]	AP-VMAT	97 ± 2	93–100	0.2
	V_105% [%]	HT	1.0 ± 1.5	0.0-5.6	0.02
	V_105% [%]	AP-VMAT	1.7 ± 1.8	0.0-8.8	0.02
PTV IMN	V_95% [%]	HT	90 ± 8	78–99	< 0.001
	V_95% [%]	AP-VMAT	98 ± 2	95–100	< 0.001
	V_105% [%]	HT	3.4 ± 3.6	0.7–11.3	0.3
	V_105% [%]	AP-VMAT	2.9 ± 4.1	0.3–13.0	0.3
PTV boost	V_95% [%]	HT	97 ± 2	96–98
	V_95% [%]	AP-VMAT	95 ± 3	93–97
	V_105% [%]	HT	2.0 ± 2.8	0.0–4.0
	V_105% [%]	AP-VMAT	0.46 ± 0.01	0.45–0.47
Heart	D_mean [Gy]	HT	3.2 ± 1.3	1.2–5.9	0.7
	D_mean [Gy]	AP-VMAT	3.4 ± 1.5	1.0-9.4	0.7
	V_10Gy [%]	HT	4.9 ± 4.5	0-14.3	0.06
	V_10Gy [%]	AP-VMAT	3 ± 5	0–25	0.06
	D_0.03 cc [Gy]	HT	28 ± 15	3–52	0.6
	D_0.03 cc [Gy]	AP-VMAT	30 ± 17	4–53	0.6
Ipsilateral lung	D_mean [Gy]	HT	11 ± 2	7–14	0.3
	D_mean [Gy]	AP-VMAT	11 ± 2	6–15	0.3
	V_5Gy [%]	HT	49 ± 11	34–91	0.7
	V_5Gy [%]	AP-VMAT	50 ± 13	29–81	0.7
	V_20Gy [%]	HT	20 ± 5	10–29	0.09
	V_20Gy [%]	AP-VMAT	17 ± 5	7–25	0.09
	V_30Gy [%]	HT	12 ± 4	5–22	0.5
	V_30Gy [%]	AP-VMAT	11 ± 4	4–18	0.5
Contralateral lung	D_mean [Gy]	HT	3.6 ± 1.9	0.7-8.0	0.004
	D_mean [Gy]	AP-VMAT	2.6 ± 1.0	1.0-4.8	0.004
	V_5Gy [%]	HT	24 ± 17	0–65	0.3
	V_5Gy [%]	AP-VMAT	8 ± 8	0–33	0.3
Contralateral breast	D_mean [Gy]	HT	8 ± 3	3–17	0.01
	D_mean [Gy]	AP-VMAT	6 ± 3	2–15	0.01
	D_0.03 cc [Gy]	HT	28 ± 9	14–50	0.3
	D_0.03 cc [Gy]	AP-VMAT	24 ± 2	18–26	0.3
Esophagus	D_mean [Gy]	HT	8 ± 2	4–11	0.001
	D_mean [Gy]	AP-VMAT	6 ± 2	3–9	0.001
	D_0.03 cc [Gy]	HT	41 ± 7	25–53	0.17
	D_0.03 cc [Gy]	AP-VMAT	36 ± 10	18–52	0.17
Spinal Cord	D_mean [Gy]	HT	4.1 ± 1.6	1.6–7.9	< 0.001
	D_mean [Gy]	AP-VMAT	2.0 ± 0.5	1.0-2.7	< 0.001
	D_0.03 cc [Gy]	HT	24 ± 7	10–34	0.6
	D_0.03 cc [Gy]	AP-VMAT	10 ± 4	3–21	0.6

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