Table 4 Univariate and multivariate analyses of progression-free and overall survival
Variables | Progression-free survival | Overall survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||||
1-year rate (%) | p-value (uni) | HR | 95% CI | p-value (multi) | 1-year rate (%) | p-value (uni) | HR | 95% CI | p-value (multi) | |
Gender | ||||||||||
Men | 40.0 | 0.159 | 74.7 | 0.271 | ||||||
Women | 49.0 | 92.3 | ||||||||
Age (year) | ||||||||||
≤ 40 | 47.6 | 0.691 | 81.0 | 0.607 | ||||||
> 40 | 38.0 | 80.5 | ||||||||
Histology | ||||||||||
Osteosarcoma | 37.5 | 0.239 | 69.7 | 0.246 | ||||||
Others | 29.3 | 94.1 | ||||||||
Spinal disease status | ||||||||||
Primary | 83.3 | 0.061 | 100.0 | 0.079 | ||||||
Metastasis | 27.2 | 77.8 | ||||||||
Time from initial diagnosis (month, continuous) | – | 0.026 | 0.979 | 0.968–0.990 | < 0.001 | – | 0.448 | |||
Treated vertebral level | ||||||||||
Single | 33.2 | 0.504 | 82.0 | 0.469 | ||||||
2–3 | 26.7 | 75.0 | ||||||||
BED (Gy5, continuous) | – | 0.897 | – | 0.194 | ||||||
PTV (cc, continuous) | – | 0.436 | – | 0.056 | 1.013 | 1.003–1.024 | 0.013 | |||
Extent of disease at the time of treatment | ||||||||||
Solitary spine involvement | 73.3 | < 0.001 | 1 | < 0.001 | 100.0 | < 0.001 | 1 | < 0.001 | ||
Multiple bone metastases | 45.5 | 6.853 | 2.205–21.296 | 75.0 | 5.991 | 0.993–36.133 | ||||
Visceral metastases | 15.7 | 5.618 | 2.301–13.715 | 69.2 | 13.404 | 3.706–48.479 | ||||