Table 3 Univariate and multivariate analyses of local control
Variables | Univariate | Multivariate | |||
|---|---|---|---|---|---|
1-year rate (%) | p-value | HR | 95% CI | p-value | |
Gender | |||||
Men | 89.8 | 0.062 | |||
Women | 63.5 | ||||
Age (year) | |||||
≤ 40 | 81.0 | 0.955 | |||
> 40 | 79.7 | ||||
Histology | |||||
Osteosarcoma | 77.4 | 0.393 | |||
Others | 75.8 | ||||
Spinal disease status | |||||
Primary | 100.0 | 0.079 | |||
Metastasis | 77.8 | ||||
Any prior radiotherapy | |||||
Yes | 100.0 | 0.854 | |||
No | 75.7 | ||||
Any prior surgery | |||||
Yes | 79.8 | 0.297 | |||
No | 75.6 | ||||
Time from initial diagnosis (month, continuous) | – | 0.811 | |||
Site of lesions | |||||
Cervical | 63.6 | 0.184 | |||
Thoracic | 85.3 | ||||
Lumbar | 71.8 | ||||
Sacral | 71.4 | ||||
Treated vertebral level | |||||
Single | 80.9 | < 0.001 | 1 | 0.032 | |
2–3 | 60.0 | 3.031 | 1.098–8.365 | ||
BED (Gy5, continuous) | – | 0.031 | |||
PTV (cc, continuous) | – | 0.747 | |||
Extent of disease at the time of treatment | |||||
Solitary spine involvement | 73.3 | 0.560 | |||
Multiple bone metastases | 72.7 | ||||
Visceral metastases | 77.2 | ||||