Thyroid V40 is a good predictor for subclinical hypothyroidism in patients with nasopharyngeal carcinoma after intensity modulated radiation therapy: a randomized clinical trial

Table 3 Univariate and multivariate cox regression analysis of subclinical and clinical hypothyroidism

Variables	Subclinical hypothyroidism		Clinical hypothyroidism
Variables	Crude HR (95% CI)	Adjusted HR (95% CI)^a	Crude HR (95% CI)	Adjusted HR (95% CI)^a
Thyroid dose-volume constraint (yes vs. no)	0.408 (0.184–0.904)	0.361 (0.155–0.841)	0.585 (0.243–1.409)	0.537 (0.209–1.383)
VS40, per cm³ increase	0.834 (0.720–0.967)	0.714 (0.574–0.887)	0.972 (0.862–1.095)	0.888 (0.749–1.051)
VS40 (≥ 3 cc vs. < 3 cc)	0.442 (0.210–0.930)	0.295 (0.121–0.721)	0.670 (0.289–1.557)	0.380 (0.135–1.070)

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