Radiation dose is associated with improved local control for large, but not small, hepatocellular carcinomas

Radiation Oncology

Table 2 Univariate and multivariate Cox regression analysis for local recurrence-free survival after radiation

		Number at risk	Cumulative probability of local recurrence %	Univariate analysis			P value	Multivariate analysis			P value
		Number at risk	Cumulative probability of local recurrence %	HR	95.0% CI		P value	HR	95.0% CI		P value
					Lower	Upper			Lower	Upper
Age	> 70 years old	27	18.5	0.943	0.341	2.605	0.910
Gender male		105	15.2	0.696	0.232	2.087	0.518
ECOG	0	63	20.6	1	reference
	1	51	11.8	0.779	0.296	2.055	0.614
	2	11	9.1	0.491	0.064	3.760	0.494
	3	1	0	0	0	-	0.988
Child-Pugh Group	A	81	18.5	1	reference
	B	34	11.8	0.984	0.322	3.005	0.977
	C	7	14.3	1.422	0.186	10.885	0.734
ALBI grade	1	23	17.4	1	reference
	2	51	17.6	1.537	0.464	5.091	0.482
	3	18	16.7	2.191	0.471	10.185	0.317
Received prior local therapy		94	18.1	2.12	0.618	7.273	0.232
Vascular invasion		128	32	1.081	0.451	2.821	0.873
Planned treatment brake		34	11.8	0.762	0.254	2.283	0.627
RT treatment modality	Proton vs. photon	36	8.3	0.446	0.131	1.524	0.198
GTV diameter	> 5 cm vs. ≤ 5 cm	78	16.7	1.388	0.552	3.487	0.485	0.883	0.326	2.393	0.807
BED₁₀	> 78 Gy vs. ≤ 78 Gy	59	8.5	0.341	0.124	0.942	0.038	0.324	0.108	0.972	0.044

Abbreviations: BED, Biologically Effective Dose; GTV, Gross tumor volume; ECOG, Eastern Cooperative Oncology Group; ALBI, Albumin-bilirubin prognostic score

ISSN: 1748-717X