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Table 1 Patient characteristics

From: Proton radiotherapy as a treatment strategy to increase survival in locally advanced pancreatic cancer in the body and tail: a retrospective study

Characteristics

All patients n = 200 (range or %)

Age, years

65 (38–88)

Gender

 

 Male

109 (54.5)

 Female

91 (45.5)

Body mass index, kg/m2

20.1 (13.2–29.0)

ECOG-PS

 

 0

141 (70.5)

 1

57 (28.5)

 2

2 (1.0)

CA19-9, U/mL

231.9 (0.1–19,500)

CEA, ng/mL

3.5 (0.5–135.1)

Pathological diagnosis

 

 Yes

132 (66.0)

 No

68 (34.0)

Tumor size, mm

36 (15–70)

Major arterial invasion

 

 CA

91 (45.5)

 SMA

37 (18.5)

 CA and SMA

72 (36.0)

UICC T classification

 

 1–3

0 (0)

 4

200 (100)

UICC N classification

 

 0

137 (68.5)

 1

60 (30.0)

 2

3 (1.5)

UICC stage

 

 I, II

0 (0)

 III

200 (100)

Bile duct invasion

 

 Positive

30 (15.0)

 Negative

170 (85.0)

Duodenal invasion

 

 Positive

18 (9.0)

 Negative

182 (91.0)

Anterior peripancreatic invasion

 

 Positive

130 (65.0)

 Negative

70 (35.0)

Posterior peripancreatic invasion

 

 Positive

200 (100)

 Negative

0 (0)

Venous invasion

 

 Positive

182 (91.0)

 Negative

18 (9.0)

Arterial invasion

 

 Positive

200 (100)

 Negative

0 (0)

Extrapancreatic nerve plexus invasion

 

 Positive

200 (100)

 Negative

0 (0)

Other organ invasion

 

 Positive

9 (4.5)

 Negative

191 (95.5)

Previous treatment

 

 Yes

106 (53.0)

  FOLFIRINOX

6 (3.0)

  GnP

16 (8.0)

  FOLFIRINOX and GnP

51 (25.5)

  Others

33 (16.5)

 No

94 (47.0)

Complete scheduled concurrent chemotherapy

 

 Yes

140 (70.0)

  GEM

123 (61.5)

  S1

17 (8.5)

  No

60 (30.0)

  Incomplete GEM

36 (18.0)

  Incomplete S1

10 (5.0)

  No concurrent chemotherapy

14 (7.0)

Median GTV volume, cc

46.3 (4.7–205.6)

Median CTV volume, cc

189.6 (53.3–424.0)

Median GTV V60GyE, %

64.2 (25.2–100)

Median CTV V60GyE, %

61.2 (30.3–97.3)

  1. ECOG-PS Eastern Cooperative Oncology Group-Performance Status, CA coeliac artery, SMA superior mesenteric artery, UICC Union for International Cancer Control, TNM tumor-node-metastasis classification 8th edition, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, GnP gemcitabine and nab-paclitaxel, GEM gemcitabine, S-1 tegafur/gimeracil/oteracil, GTV gross tumor volume, CTV clinical target volume, GyE Gy equivalents, V60GyE the volume ratio irradiated over 60 GyE