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Table 6 Organ at risk dosimetry of patients with grade 3 or higher toxicity

From: Ten fraction hypofractionated stereotactic body radiotherapy for the management of ultracentral lung tumors: a retrospective analysis of dosimetry, outcomes, and toxicity

 

Prior irradiation

MLD (Gy)

TL V40 (%)

ESO Dmax (Gy)

ESO V40 (cc)

BT Dmax (Gy)

BT V50 (cc)

GV Dmax (Gy)

GV V50 (cc)

Reference constraint [10, 23]

Toxicity

Pneumonitis

         

MLD ≤ 9 Gy

 Patient 1

60 Gy/30fx

12.6

2

      

TL V40 ≤ 7%

 Patient 2

70.2 Gy/39fx

6.3

2.2

       

 Patient 3

10.5

3.4

       

Esophagitis

         

ESO Dmax ≤ 50 Gy

 Patient 2

70.2 Gy/39fx

  

57.8

6.33

    

ESO V40 ≤ 1 cc

Airway toxicity

         

BT Dmax ≤ 60 Gy

 Patient 4

     

73.6

7.7

  

BT V50 ≤ 1 cc

 Patient 5

     

79.1

4.2

   

Hemorrhage

         

BT Dmax ≤ 60 Gy

 Patient 6

70 Gy/35fx

    

72.6

4.9

72.9

5.42

BT V50 ≤ 1 cc

 Patient 7

50 Gy/5fx

    

77.4

5.7

73.7

16.8

GV Dmax ≤ 75 Gy

 Patient 8

    

75

1.94

57.3

3.2

GV V50 ≤ 1 cc

  1. Vx: volume (percentage or cubic centimeters) of tissue exposed to x Gy or more, Dmax: maximum dose, MLD: mean lung dose, TV: total lung, ESO: esophagus, BT: bronchial tree, GV: great vessel, fx: treatment fractions, Gy: Gray