Table 4 Dosimetric paraneters
Characteristic | Entire patient cohort (N = 78) | No prior in-field radiotherapy (N = 50) | Re-irradiation (N = 28) | p-value |
|---|---|---|---|---|
PTV volume (cc): median (range) | 66.6 (9.3–1201.8) | 89.3 (9.3–1201.8) | 62.0 (12.2–210.7) | 0.03 |
Dose fractionation (total dose in Gy/fraction) | 0.21 | |||
70/10 | 23 (29.5) | 19 | 4 | |
65/10 | 22 (28.2) | 12 | 10 | |
63/10 | 1 (1.3) | 0 | 1 | |
60/10 | 6 (7.7) | 3 | 3 | |
50/10 | 22 (28.2) | 13 | 9 | |
42.5/10 | 1 (1.3) | 1 | 0 | |
40/10 | 3 (3.8) | 2 | 1 | |
Dose (Gy): median (range) | 65.0 (40–70) | 65.0 (40–70) | 64.0 (40–70) | 0.23 |
BED10 (Gy): median (range) | 107.25 (56–119) | 107.25 (56–119) | 104.97 (50–119) | 0.17 |
Total lung | ||||
V5 (%): median (IQR) | 24.0 (15.0, 41.7) | 27.4 (16.7, 41.7) | 19.3 (11.6, 36.3) | 0.17 |
V20 (%): median (IQR) | 8.0 (4.5, 17.2) | 9.6 (5.2, 17.8) | 7.8 (3.4, 11.0) | 0.22 |
V40 (%): median (IQR) | 3.2 (1.3, 5.8) | 4.1 (1.5, 6.5) | 2.3 (1.1, 5.1) | 0.15 |
MLD (Gy): median (IQR) | 11.5 (6.7,16.8) | 12.3 (8.7, 18.7) | 9.9 (4.7, 12.6) | 0.01 |
Esophagus | ||||
Dmax (Gy): median (IQR) | 37.52 (24.4, 48.9) | 41.6 (26.5, 52.9) | 31.3 (21.3, 42.1) | 0.09 |
V40 (cc): median (IQR) | 0 (0, 0.6) | 0 (0, 0.7) | 0 (0, 0.01) | 0.1 |
Primary bronchial tree/Trachea | ||||
Dmax (Gy): median (IQR) | 59.9 (45.5, 75.2) | 55.6 (42.1, 77.3) | 64.0 (49.8, 73.3) | 0.81 |
V50 (cc): median (IQR) | 0.96 (0, 3.86) | 1.0 (0, 3.9) | 1.0 (0, 3.2) | 0.73 |
Great vessel | ||||
Dmax (Gy): median (IQR) | 68.2 (53.5, 76.6) | 68.2 (47.1, 74.0) | 69.2 (55.1, 77.5) | 0.23 |
V50 (cc): median (IQR) | 3.53 (0.1, 9.7) | 3.2 (0, 13.1) | 4.2 (0.8, 5.9) | 0.18 |