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Table 3 Univariate logistic regression model: Factors associated with local control of tumor, progression free survival and overall survival

From: Ten fraction hypofractionated stereotactic body radiotherapy for the management of ultracentral lung tumors: a retrospective analysis of dosimetry, outcomes, and toxicity

Characteristic

Local control

Progression free survival

Overall survival

OR (95% CI)

p-value

OR (95% CI)

p-value

OR (95% CI)

p-value

SBRT total dose

1.05 (0.98–1.19)

0.15

0.97 (0.90–1.05)

0.51

1.03 (0.97–1.10)

0.3

SBRT BED10

1.02 (0.99–1.05)

0.13

0.99 (0.95–1.03)

0.53

1.02 (0.97–1.05)

0.3

Metastatic or recurrent disease (reference = primary disease)

1.63 (0.54–4.93)

0.38

1.48 (0.39–5.61)

0.56

0.78 (0.27–2.30)

0.65

Re-irradiation (reference = no prior radiation)

2.70 (0.92–7.92)

0.07

0.56 (0.15–2.12)

0.39

1.24 (0.41–3.72)

0.7

Histology (reference = other)

 Adenocarcinoma

0.63 (0.01–62.45)

0.77

3.26 (0.03–337.09)

0.61

0.75 (0.01–73.55)

0.9

 Squamous cell carcinoma

1.78 (0.02–173.35)

0.12

2.28 (0.02–238.09)

0.72

0.72 (0.01–72.60)

0.89

Tumor location (reference = lung parenchyma + hilum)

 Mediastinum

1.02 (0.19–6.70)

0.98

0.87 (0.15–5.23)

0.88

1.40 (0.29–6.69)

0.67

 Hilum

1.66 (0.37–9.99)

0.55

1.80 (0.29–11.23)

0.52

0.36 (0.07–1.98)

0.24

 Mediastinum + hilum

1.64 (0.29–11.14)

0.59

6.42 (0.25–167.81)

0.26

0.91 (0.15–5.42)

0.91

ITV

1.00 (0.97–1.01)

0.78

0.99 (0.99–1.00)

0.11

1.00 (0.99–1.00)

0.27

PTV

1.00 (0.99–1.00)

0.73

0.99 (0.99–1.00)

0.1

1.00 (0.99–1.00)

0.29

D98

1.03 (0.97–1.09)

0.28

0.98 (0.92–1.07)

0.74

1.03 (0.97–1.09)

0.34

D99

1.03 (0.98–1.09)

0.27

0.99 (0.91–1.07)

0.78

1.02 (0.97–1.09)

0.41

PET SUV max

1.00 (0.90–1.12)

0.98

0.99 (0.85–1.16)

0.91

0.94 (0.80–1.09)

0.4

Age

0.99 (0.94–1.03)

0.64

1.05 (0.99–1.12)

0.12

0.99 (0.92–1.02)

0.22

Sex (reference = female)

1.75 (0.61–5.06)

0.3

0.81 (0.21–3.07)

0.76

2.06 (0.69–6.13)

0.2

  1. SBRT: stereotactic body radiation therap, BED10: biologic effective dose, ITV: internal target volume, PTV: planning target volume, D98: minimum dose covering 98% of the target volume, D99: minimum dose covering 99% of the target volume, PET: positron emission tomography, SUV: standardized uptake value, OR: odds ratio, CI: confidence interval