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Table 2 Dosimetric comparison between intracavitary BT vs. intracavitary + interstitial BT vs. SBRT

From: Boost modalities in cervical cancer: dosimetric comparison between intracavitary BT vs. intracavitary + interstitial BT vs. SBRT.

Structures

Mean (SEM) Dose (Gy)

IC-BT vs. SBRT

IC-BT vs. IC-BT + IS

IC-BT + IS vs. SBRT

IC-BT vs. IC-BT + IS vs. SBRT

 

IC-BT

IC-BT + IS

SBRT

    

OAR’s normalization

      

D30_HR_CTV

14.9

(14.16-15-64)

15.2

(14.65–15.75)

10.1

(9.93–10.27)

P < .001

P = .37

P < .001

P < .001

D50_HR_CTV

11.1

(10.57–11.63)

12.1

(11.67–12.53)

9.83

(9.61–10.05)

P = .005

P < .001

P < .001

P = .001

D90_HR_CTV

6.62

(6.24-7)

7.8

(7.51–8.09)

9.02

(8.75–9.29)

P < .001

P < .001

P < .001

P < .001

Target normalization

   

D2cc_Bladder

6.46

(6.13–6.79)

5.49

(5.25–5.73)

4.99

(4.85–5.13)

P < .001

P < .001

P = .002

P < .001

D2cc_Bowel

2.82

(2.47–3.17)

2.48

(2.16–2.8)

2.06

(1.69–2.43)

P < .001

P < .001

P = .07

P < .001

D2cc_Rectum

3.87

(3.6–4.14)

3.58

(3.34–3.82)

2.71

(2.54–2.88)

P < .001

P = .03

P < .001

P = .003

D2cc_Sigmoid

3.65

(3.3-4)

3.11

(2.8–3.41)

2.59

(2.27–2.91)

P < .001

P < .001

P < .001

P = .08

  1. Abbreviation: SEM: standard deviation of mean; Gy: Gray; IC-BT: Intracavitary brachytherapy; IC-BT + IS: Intracavitary plus interstitial brachytherapy; SBRT: Stereotactic Body Radiotherapy; HR-CTV: High-risk clinical target volume; D30-50-90: defined as the minimum dose covering 30-50-90% of the volume; OARs: organs at risk; D2cc: defined as the minimal dose of the 2 cc the volume