Table 1 Patient characteristics
From: Chemoradiation for oesophageal cancer: the choice of treatment modality
All n | definitive chemoradiation n | neoadjuvant chemoradiation and surgery n | p | |
|---|---|---|---|---|
149 (100%) | 85 (57.0%) | 64 (43.0%) | ||
Gender | 0.732 | |||
Male | 94 (63.1%) | 55 (64.7%) | 39 (60.9%) | |
Female | 55 (36.9%) | 30 (35.3%) | 25 (39.1%) | |
Median age at diagnosis (range) | 65 (39–80) | 64 (47–78) | 65 (39–80) | 0.372 |
ECOG performance status | < 0.005 | |||
0 | 24 (16.1%) | 6 (7.1%) | 18 (28.1%) | |
1 | 102 (68.5%) | 59 (69.4%) | 43 (67.2%) | |
2 | 23 (15.4%) | 20 (23.5%) | 3 (4.7%) | |
Smoking | 0.186 | |||
Never | 24 (16.1%) | 9 (10.6%) | 15 (23.4%) | |
Current smoker | 77 (51.7%) | 48 (56.5%) | 29 (45.3%) | |
Ex-smoker | 37 (24.8%) | 21 (24.7%) | 16 (25.0%) | |
Unknown | 11 (7.4%) | 7 (8.2%) | 4 (6.3%) | |
BMI median (range) | 22.8 (13.3–42.6) | 22.9 (13.3–42.6) | 22.8 (16.6–34.4) | 0.445 |
Histology | 0.665 | |||
Squamous cell carcinoma | 126 (84.6%) | 69 (81.2%) | 57 (89.1%) | |
Adenocarcinoma | 13 (8.7%) | 9 (10.6%) | 4 (6.3%) | |
Other | 10 (6.7%) | 7 (8.2%) | 3 (4.7%) | |
Lesion location | 0.005 | |||
Upper | 30 (20.1%) | 25 (29.4%) | 5 (7.8%) | |
Middle | 70 (47.0%) | 35 (41.2%) | 35 (54.7%) | |
Lower | 49 (32.9%) | 25 (29.4%) | 24 (37.5%) | |
Stage 8th AJCC | 0.002 | |||
I | 2 (1.3%) | 1 (1.2%) | 1 (1.6%) | |
II | 35 (23.5%) | 14 (16.5%) | 21 (32.8%) | |
III | 60 (40.3%) | 29 (34.1%) | 31 (48.4%) | |
IVa | 35 (23.5%) | 26 (30.6%) | 9 (14.1%) | |
IVb | 17 (11.4%) | 15 (17.6%) | 2 (3.1%) | |
Median dose, Gy (range) | 50.4(41.4–70) | 50.4 (41.4–70) | 45 (41.4–66) | < 0.0001 |
Radiotherapy modality | 0.116 | |||
3D CRT | 22 (14.8%) | 14 (16.5%) | 8 (12.5%) | |
IMRT | 56 (37.6%) | 37 (43.5%) | 19 (29.7%) | |
VMAT | 70 (47%) | 34 (40.0%) | 36 (56.3%) | |
PTV cm3, median (range) | 554.8 (121.4–1821.3) | 639.2 (199.1–1490.5) | 467.2 (121.4–1821.3) | 0.009 |
PTV cm, median (range) | 16.6 (8.6–31.4) | 17.6 (8.7–29.9) | 15.5 (8.6–31.4) | 0.033 |
Late toxicity after chemoradiation | ||||
Pneumonitis | 0.238 | |||
Grade 1–2 | 14 (9.4%) | 10 (11.8%) | 4 (6.3%) | |
Grade 3–4 | 4 (2.7%) | 1 (1.2%) | 3 (4.7%) | |
Oesophageal stricture, any grade | 28 (18.8%) | 13 (15.3%) | 15 (23.4%) | 0.063 |
Fistula, any grade | 27 (18.1%) | 16 (18.8%) | 11 (17.2%) | 0.76 |