Impact of planning organ at risk volume margins and matching method on late gastrointestinal toxicity in moderately hypofractionated IMRT for locally advanced pancreatic ductal adenocarcinoma

Table 2 Summary of late gastrointestinal toxicity for all cases

Protocol	Age (yr)	Primary Site	TNM (UICC 7th)	GTV (cm³)	PTV (cm³)	Overlap (cm³)	Late toxicity	Grade (CTCAEv.5)	Form and Location	Interval^* (months)	OS^** (months)
B	48	Head	T4N0M0	31.3	178.7	43.4	Hemorrhage	Grade 4	Duodenal bulb ulcer	4.9	39.8
B	61	Head	T4N0M0	47.9	254.7	33.3	Ulcer	Grade 2	Stomach vestibule ulcer	10.9	41.1
B	69	Head	T4N1M1	53.2	452.3	366.9	Hemorrhage	Grade 3	Stomach vestibule gastritis	3.5	6.6
B	64	Head	T4N0M0	15.2	165.8	155.7	Hemorrhage +ulcer	Grade 4 Grade 2	GDA pseudoaneurysm Duodenal bulb ulcer	5.1	63.7
B	59	Head	T4N1M0	25.6	204.5	176.2	Hemorrhage	Grade 3	Stomach vestibule gastritis	5.3	10.3
B	66	Body	T3N0M1	4.0	129.4	119.7	Hemorrhage	Grade 3	Stomach vestibule gastritis	9.5	80.8
B	82	Head	T3N0M1	2.4	193.5	162.7	Ulcer	Grade 2	Stomach angle ulcer	8.2	46.8
B	56	Head	T4N1M1	21.9	197	156.9	Hemorrhage	Grade 4	Brunch of SMA pseudoaneurysm	5.5	35.0
A	73	Body	T3N1M1	74.6	483.4	105.2	Hemorrhage	Grade 3	Duodenal bulb ulcer	6.7	18.7

Abbreviations: GTV, gross tumor volume; PTV, planning target volume; GDA, gastro duodenal artery; OS, overall survival; SMA, superior mesenteric artery
^* Calculated from start of radiotherapy, the first event date after 3 months was used
^** Calculated from start of chemotherapy

ISSN: 1748-717X