Table 1 The predictive role of radiosensitivity in radiotherapy and immunotherapy

Tobin et al. (2017) [74]

Breast cancer

282

RSI-low status that refer to more radiosensitive tumor (HR 0.58, 95% CI 0.34-1.00; p = 0.05) and 12-CK-high status that refer to more immune-active tumor (HR 0.61,95% CI 0.39–0.96; p = 0.03) were independently related with improved distant metastasis free survival.

Dai et al. (2021) [75]

11 major cancer types

12,832 primary tumors and 585 metastatic tissues

RSI was significantly associated with immune-related molecular features(p < 0,05). RSI-Low tumors carried more higher portion of follicular T helper cells, T cell gamma delta cells, activated NK cells and M1 macrophages than RSI-High tumors.

Grass et al. (2022) [87]

31 primary tumors types

10,469

 A weak negative relevance between the RSI and immune score (Pearson’s r = − 0.28; Spearman’s r = − 0.27, P < 0.001). Tumors with high radiosensitivity showed significant enrichment of IFN-related signaling pathways and immune cell infiltration (i.e., CD8⁺ T cells, activated NK cells, M1-macrophages, q < 0.05).