Table 4 Univariate and multivariate model of local progression free survival (n = 103)
From: Fractionated stereotactic radiotherapy of brain metastases: results of a retrospective study
Univariate model | Multivariate model | |||||
|---|---|---|---|---|---|---|
Characteristics | HR | 95%CI | P - value | HR | 95%CI | P - value |
Gross tumor volume (cm³) | ||||||
≤ 1.5cm³ (reference) | ||||||
> 1.5cm³ | 1.016 | 0.442, 2.336 | 0.969 | 2.063 | 0.717, 5.933 | 0.179 |
Extracranial metastases | ||||||
No (reference) | ||||||
Yes | 4.141 | 1.500, 11.430 | 0.006 | 4.504 | 0.752, 26.966 | 0.099 |
Control of primary cancer | ||||||
Control (reference) | ||||||
No control | 0.955 | 0.287, 3.180 | 0.940 | 2.278 | 0.534, 9.716 | 0.266 |
Karnofsky performance score (KPS) | 0.986 | 0.957, 1.016 | 0.358 | 0.985 | 0.921, 1.053 | 0.650 |
Systemic treatment * 3 months before/after FSRT | ||||||
Yes (reference) | ||||||
No | 1.551 | 0.582, 4.134 | 0.380 | 0.956 | 0.299, 3.057 | 0.939 |
Number of brain metastases | 1.699 | 1.232, 2.343 | 0.001 | 2.353 | 1.374, 4.028 | 0.002 |
Patient age | 1.007 | 0.978, 1.036 | 0.648 | 1.067 | 0.998, 1.142 | 0.059 |
Recursive partitioning analysis (RPA) | 1.275 | 0.691, 2.352 | 0.437 | 1.182 | 0.615, 2.273 | 0.616 |
Diagnosis-specific graded prognostic assessment (dsGPA) | 0.584 | 0.373, 0.916 | 0.019 | 2.386 | 0.495, 11.491 | 0.278 |
Histology | ||||||
Malignant melanoma/renal cell cancer (reference) | ||||||
Other | 0.500 | 0.233, 1.072 | 0.075 | 0.155 | 0.049, 0.492 | 0.002 |
Cerebral progression outside the planning target volume | ||||||
No (reference) | ||||||
Yes | 0.830 | 0.381, 1.807 | 0.639 | 1.508 | 0.566, 4.018 | 0.411 |