Table 3 Univariate and multivariate Cox regression analysis on OS, PFS and IHPFS in the whole cohort

Group (refer to LEN)

0.43 (0.27–0.70)

0.001

0.37 (0.23–0.60)

0.000

0.41 (0.27–0.63)

0.000

0.33 (0.21–0.51)

0.000

0.38 (0.25–0.59)

0.000

0.29 (0.18–0.45)

0.000

Gender (refer to Male)

1.21 (0.65–2.28)

0.548

1.53 (0.87–2.70)

0.145

1.28 (0.73–2.25)

0.390

Age (refer to < 55 years)

1.01 (0.67–1.52)

0.960

1.11 (0.76–1.62)

0.605

1.10 (0.74–1.60)

0.668

Etiology (refer to HBV)

1.49 (0.64–3.45)

0.356

0.93 (0.41–2.12)

0.864

0.96 (0.42–2.20)

0.924

Child–Pugh classification (refer to A)

1.87 (1.09–3.23)

0.024

1.15 (0.63–2.11)

0.655

1.57 (0.93–2.65)

0.089

1.28 (0.74–2.20)

0.382

1.68 (1.00–2.84)

0.052

1.38 (0.80–2.38)

0.248

ECOG PS (refer to 0)

1.71 (1.12–2.62)

0.013

1.37 (0.85–2.20)

0.199

1.35 (0.92–1.98)

0.127

1.34 (0.91–1.97)

0.135

Number of tumors (refer to ≤ 3)

1.79 (1.18–2.71)

0.006

1.73 (1.11–2.72)

0.017

1.83 (1.25–2.68)

0.002

2.05 (1.36–3.09)

0.001

1.77 (1.21–2.59)

0.004

2.05 (1.35–3.12)

0.001

Tumor size (refer to < 5 cm)

1.21 (0.92–1.61)

0.180

1.11 (0.86–1.44)

0.429

1.10 (0.84–1.42)

0.491

PVTT (refer to Vp1)

2.16 (1.56–2.99)

0.000

1.95 (1.37–2.77)

0.000

1.50 (1.14–1.97)

0.004

1.52 (1.13–2.04)

0.005

1.46 (1.11–1.92)

0.008

1.45 (1.08–1.95)

0.014

ALBI grade (refer to 1)

1.40 (0.88–2.23)

0.155

1.10 (0.73–1.67)

0.641

1.07 (0.71–1.62)

0.742

AFP (refer t  ≤ 200 ng/mL)

1.54 (1.02–2.32)

0.039

1.24 (0.81–1.89)

0.317

1.57 (1.07–2.31)

0.021

1.39 (0.94–2.05)

0.097

1.51 (1.03–2.21)

0.036

1.37 (0.92–2.02)

0.119

PLT (refer to < 100 × 109/L)

0.81 (0.51–1.31)

0.396

0.91 (0.59–1.42)

0.684

0.93 (0.59–1.44)

0.732

WBC (refer to < 4 × 109/L)

0.84 (0.54–1.30)

0.429

0.69 (0.46–1.04)

0.078

0.67 (0.43–1.02)

0.063

0.68 (0.45–1.03)

0.072

0.66 (0.43–1.02)

0.063

Previous local treatment (refer to Absence)

0.77 (0.39–1.53)

0.454

0.95 (0.52–1.74)

0.870

0.86 (0.47–1.57)

0.623