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Table 2 Cox univariate analysis of the ARS and OS for 30 ESCC patients treated with Re-RT

From: Re-irradiation for local primary-recurrence esophageal squamous cell carcinoma treated with IMRT/VMAT

Variable

n(%)

OS

ARS

HR(95%CI)

P

HR(95%CI)

P

Gender

 

0.578(0.232–1.441)

0.240

1.959(0.765–5.011)

0.161

Male

24(80.0)

    

Female

6(20.0)

    

Age

 

1.124(0.501–2.518)

0.777

0.855(0.386–1.891)

0.698

≤ 65

10(33.3)

    

> 65

20(66.7)

    

Alcohol abuse

 

2.082(0.958–4.525)

0.064*

0.936(0.449–1.953)

0.861

Yes

13(43.3)

    

No

17(56.7)

    

Smoking

 

2.265(1.037–4.950)

0.040*

0.773(0.367–1.628)

0.498

Yes

13(43.3)

    

No

17(56.7)

    

PS

 

1.253(0.542–2.894)

0.598

1.057(0.464–2.406)

0.896

1

11(36.7)

    

2

19(63.3)

    

T stage#

 

1.112(0.448–2.759)

0.819

1.226(0.492–3.057)

0.661

1/2

6(20.0)

    

3/4

24(80.0)

    

N stage#

 

1.920(0.858–4.298)

0.112

1.040(0.480–2.251)

0.922

0

11(36.7)

    

1/2

19(63.3)

    

Clinical stage#

 

1.596(0.742–3.434)

0.232

1.362(0.648–2.863)

0.415

I/II

13(43.3)

    

III/IV

17(56.7)

    

Tumor location#

 

1.269(0.611–2.638)

0.523

1.137(0.525–2.462)

0.745

Upper and middle thoracic

15(50.0)

    

Lower thoracic

15(50.0)

    

Tumor length(cm)#

 

1.641(0.770–3.498)

0.199

1.239(0.589–2.606)

0.572

≤ 5

18(60.0)

    

> 5

12(40.0)

    

RFI (months)

 

0.102(0.036–0.289)

< 0.001*

0.774(0.349–1.717)

0.529

≤ 12

9(30.0)

    

> 12

21(70.0)

    

Re-RT field

 

1.232(0.493–3.081)

0.655

1.243(0.497–3.110)

0.642

In field

24(80.0)

    

Marginal

6(20.0)

    

Concurrent chemotherapy

 

1.660(0.773–3.563)

0.193

1.818(0.840–3.934)

0.129

Yes

13(43.3)

    

No

17(56.7)

    

Chemotherapy for both course treatment

 

1.504(0.689–3.281)

0.305

2.162(0.951–4.914)

0.066

Yes

10(33.3)

    

No

20(66.7)

    

Re-Radiotherapy technique

 

0.929(0.426–2.026)

0.853

1.490(0.680–3.268)

0.319

IMRT

10(33.3)

    

VMAT

20(66.7)

    

Initial radiation dose (Gy)

 

0.521(0.247–1.097)

0.086*

0.800(0.383–1.670)

0.552

≤ 60

13(43.3)

    

> 60

17(56.7)

    

Re-RT dose (Gy)

 

1.082(0.514–2.277)

0.835

0.846(0.398–1.799)

0.664

≤ 50

12(40.0)

    

> 50

18(60.0)

    

Total radiation dose (Gy)

 

0.757(0.364–1.575)

0.363

0.689(0.329–1.442)

0.322

≤ 115

15(50.0)

    

> 115

15(50.0)

    
  1. * Univariate analysis was used to calculate the p value of variables, and then multivariate analysis was performed for variables with p < 0.1 to analyze independent risk factors
  2. # Variables at initial diagnosis
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Radiation Oncology

ISSN: 1748-717X

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