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Table 2 Clinical characteristics by boost modality (propensity score matched)

From: Dose escalation in oropharyngeal cancer: a comparison of simultaneous integrated boost and brachytherapy boost

Clinical characteristics

Overall

SIB

Brachy

SMD

Number (%)

Number

162

81

81

 

HPV status

   

0.164

 Negative

21 (13.0)

10 (12.3)

11 (13.6)

 

 Positive

140 (86.4)

71 (87.7)

69 (85.2)

 

 Unknown

1 (0.6)

0 (0.0)

1 (1.2)

 

Age ≥ median (62 years)

85 (52.5)

41 (50.6)

44 (54.3)

0.074

Tumour stage*

   

0.079

 I-II

10 (6.2)

5 (6.2)

5 (6.2)

 

 III

18 (11.1)

8 (9.9)

10 (12.3)

 

 IV

134 (82.7)

68 (84.0)

66 (81.5)

 

Tumour site

   

0.584

 Base of tongue

90 (55.6)

34 (42.0)

56 (69.1)

 

 Tonsil

66 (40.7)

44 (54.3)

22 (27.2)

 

 Other

6 (3.7)

3 (3.7)

3 (3.7)

 

Performance status at start of radiotherapy

   

 < 0.001

 0

144 (88.9)

72 (88.9)

72 (88.9)

 

 1

16 (9.9)

8 (9.9)

8 (9.9)

 

 2

2 (1.2)

1 (1.2)

1 (1.2)

 

Male gender

127 (78.4)

63 (77.8)

64 (79.0)

0.030

Concurrent medical treatment

   

0.094

 Cetuximab

80 (49.4)

41 (50.6)

39 (48.1)

 

 Cetuximab + Cisplatin

7 (4.3)

4 (4.9)

3 (3.7)

 

 Cisplatin

55 (34.0)

26 (32.1)

29 (35.8)

 

 None

20 (12.3)

10 (12.3)

10 (12.3)

 

Induction chemotherapy

45 (27.8)

23 (28.4)

22 (27.2)

0.028

Medical treatment (concurrent or induction)

144 (88.9)

72 (88.9)

72 (88.9)

 < 0.001

Cisplatin containing medical treatment

90 (55.6)

45 (55.6)

45 (55.6)

 < 0.001

  1. SIB Simultaneous integrated boost, Brachy Brachytherapy boost in combination with external beam radiotherapy, HPV Human papillomavirus, SMD Standardized mean difference
  2. *Tumour stage according to the American Joint Committee on Cancer’s (AJCC) Cancer-Staging Manual, 7th edition