Table 4 Grade 3–4 adverse events
Acute adverse events | Late adverse events | ||||
|---|---|---|---|---|---|
Events | Grade 3 | Grade 4 | Events | Grade 3 | Grade 4 |
Hematologic | Â | Â | Temporal lobe injury | 25 (5%) | 0 |
Anaemia | 9 (2%) | 0 | Cranial neuropathy | 18 (4%) | 0 |
Thrombocytopaenia | 0 | 0 | Peripheral neuropathy | 9 (2%) | 0 |
Neutropenia | 62 (14%) | 5 (1%) | Eye damage | 0 | 0 |
Leukopenia | 98 (21%) | 1 (< 1%) | Ear (deafness/otitis) | 35 (8%) | 4 (1%) |
Nonhematologic | Â | Â | Bone necrosis | 0 | 0 |
Dermatitis | 16 (4%) | 0 | soft tissue damage | 11 (2%) | 0 |
Mucositis | 78 (17%) | 7 (2%) | Trismus | 6 (1%) | 0 |
Dysphagia | 19 (4%) | 0 | Dry mouth | 16 (4%) | 0 |
Nausea | 23 (5%) | 0 | Â | Â | Â |
Vomiting | 40 (8%) | 0 | Â | Â | Â |
Dry mouth | 9 (2%) | 0 | Â | Â | Â |