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Fig. 7 | Radiation Oncology

Fig. 7

From: Systematic in vitro analysis of therapy resistance in glioblastoma cell lines by integration of clonogenic survival data with multi-level molecular data

Fig. 7

CpG methylation status of leading edge intersect genes shows poor correlation between DNA methylation and therapy resistance. Correlation analyses of DNA methylation beta values (shown in purple) and relative log2 mRNA expression levels (shown in green) of leading edge intersect genes of the REACTIVE_OXYGEN_SPECIES_PATHWAY, MTORC1_SIGNALING, and TNFA_SIGNALING_VIA_NFKB hallmark gene sets. Coefficients of significant negative correlation are depicted by heat map clustering (shown in dark pink), and scaled resistance scores to single-shot and fractionated RTX (REACTIVE_OXYGEN_SPECIES_PATHWAY), or single-shot RTX + TMZ (MTORC1_SIGNALING, and TNFA_SIGNALING_VIA_NFKB) are shown by unsupervised hierarchical clustering

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Radiation Oncology

ISSN: 1748-717X

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