Fig. 6

Leading edge analyses (LEAs) via functional interaction networks and hierarchical clustering. a Functional interaction networks of the leading edge intersect genes in hallmark gene sets REACTIVE_OXYGEN_SPECIES_PATHWAY, MTORC1_SIGNALING, and TNFA_SIGNALING_VIA_NFKB as identified by GSEA in Fig. 5A. b Hierarchical clustering of relative log2 mRNA expression levels of the respective leading edge intersect genes. Scaled scores of inherent therapy resistances are shown by unsupervised hierarchical clustering, and drugs antagonizing the respective gene products are indicated in red