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Fig. 4 | Radiation Oncology

Fig. 4

From: Systematic in vitro analysis of therapy resistance in glioblastoma cell lines by integration of clonogenic survival data with multi-level molecular data

Fig. 4

Integration of mRNA expression data of cancer gene consensus (CGC) genes with inherent therapy resistance in glioblastoma cell lines. a Intersect analysis of CGC genes whose log2 mRNA expression levels show significant positive (R ≥ 0.7) correlation with inherent resistance to single-shot RTX (blue), fractionated RTX (red), TMZ (green), and single-shot RTX + TMZ (yellow, left). Hierarchical clustering of relative log2 mRNA expression levels of 11 intersect genes correlating with resistance to single-shot RTX, fractionated RTX, and single-shot RTX + TMZ (right). Scaled scores of resistance to single-shot RTX + TMZ are depicted, and drugs antagonizing corresponding gene products are indicated in red. b Overlap analysis of CGC genes whose log2 mRNA expression shows significant negative (R ≤ -0.7) correlation with inherent resistance to single-shot RTX, fractionated RTX, TMZ and single-shot RTX + TMZ, and hierarchical clustering of relative log2 mRNA expression levels of 11 intersect genes

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Radiation Oncology

ISSN: 1748-717X

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