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Table 1 Patients characteristics stratified by cohort (PBT and CRT) before and after propensity matching

From: High-dose proton beam therapy versus conventional fractionated radiation therapy for newly diagnosed glioblastoma: a propensity score matching analysis

 

Before propensity score matching (n = 235)

After propensity score matching (n = 52)

 

PBT (n = 26)

CRT (n = 209)

p value

PBT (n = 26)

CRT (n = 26)

p value

Age (y), mean ± SD

57.6 ± 12.3

62.5 ± 13.1

0.075

57.6 ± 12.3

54.3 ± 14.3

0.37

Sex, female (%)

11 (42.3%)

87 (41.6%)

1.000

11 (42.3%)

7 (26.9%)

0.382

Tumor location (cerebral lobe) (%)

25 (96.2%)

171 (81.8%)

0.090

25 (96.2%)

26 (100%)

1

Extent of resection (GTR, STR) (%)

23 (88.5%)

122 (58.4%)

0.002

23 (88.5%)

19 (73.1%)

0.291

Temozolomide (%)

26 (100%)

205 (98.1%)

1.000

26 (100%)

25 (96.2%)

1

Immunotherapy (%)

5 (19.2%)

22 (10.5%)

0.195

5 (19.2%)

6 (23.1%)

1

KPS (pre RT)  ≥ 70 (%)

23 (88.5%)

140 (67.0%)

0.025

23 (88.5%)

22 (84.6%)

1

MGMT methyl (%)

1/21 (4.8%)

47/146 (32.2%)

0.009

1/21 (4.8%)

3/18 (16.7%)

0.318

IDH mut (%)

3/23 (13.0%)

9/181 (5.0%)

0.140

3/23 (13.0%)

1/18 (5.6%)

0.618

  1. GTR Gross total resection, STR Subtotal resection, KPS Karnofsky performance scale, MGMT O6-methylguanine-DNA-methyltransferase, IDH isocitrate dehydrogenase