A radiomics model for predicting the response to methylprednisolone in brain necrosis after radiotherapy for nasopharyngeal carcinoma

Table 2 Potential predictors of the response to steroid in patients with brain necrosis

Variable	Univariate logistic regression		Multivariate logistic regression
Variable	OR (95%CI)	P*	OR (95%CI)	P
Age, years	1.008 (0.954–1.065)	0.774
Sex		0.955
Male	Reference
Female	0.965 (0.282–3.302)
Radiomics score (per 0.1 increase)	2.172 (0.476–9.916)	< 0.001^*	3.388 (0.538–21.334)	< 0.001
DBRN, months	0.992 (0.983–1.000)	0.050^*	1.020 (1.001–1.040)	0.034
DBRM, months	0.997 (0.981–1.012)	0.664
DBNM, months	0.992 (0.958–1.028)	0.674
AST, U/L	1.029 (0.939–1.128)	0.543
ALT, U/L	0.989 (0.942–1.038)	0.655
Hs-CRP, mg/L	0.999 (0.978–1.021)	0.947
D_max of the GTVnx,Gy	1.130 (0.910–1.404)	0.269
D_max of the GTVnd,Gy	1.082 (0.947–1.237)	0.246
Dmax of the temporal lobe, Gy	0.982 (0.827–1.167)	0.838
Radiotherapy methods		0.481
Conventional radiotherapy	Reference
IMRT	0.545 (0.101–2.944)
MOCA		0.048^*
< 26	Reference
≥ 26	0.357 (0.129–0.992)
LENT-SOMA^#	0.917 (0.840–1.000)	0.050^*
NPC stage		0.469
II	Reference
III	4.286 (0.438–41.954)	0.211
IV	2.000 (0.191–20.898)	0.563
IVA	3.125 (0.278–35.157)	0.356
Steroid dose, mg/d		0.246
80	Reference
500	1.833 (0.658–5.107)

DBRN, duration between radiotherapy and radiation-induced brain necrosis (RN) diagnosis; DBRM, duration between radiotherapy and methylprednisolone treatment; DBNM, duration between RN diagnosis and methylprednisolone treatment; AST, aspartate transaminase; ALT, alanine transaminase; Hs-CRP, high-sensitivity C-reaction protein levels; Dmax of the GTVnx, the maximum radiation dose of the nasopharynx; Dmax of the GTVnd, the maximum radiation dose of the neck; IMRT, intensity-modulated radiation therapy; MoCA, montreal cognitive assessment score; LENT-SOMA, the late effects of normal tissue (LENT)/subjective, objective, management, analytic (SOMA) scale score; NPC, nasopharyngeal carcinoma
*P < 0.02; ^#summary grade of the Subjective, Objective, and Management (SOM) characteristics

ISSN: 1748-717X