Table 3 Results of the mixed linear model for each immune-related molecule

Treatment

Treatment success group (Comparison object)

0.0

–

0.0

–

0.0

–

0.0

–

0.0

–

0.0

–

0.0

–

Treatment failure group

0.3 ± 1.1

0.82

3.8 ± 7.3

0.61

− 6.6 ± 2.8

0.02

0.0 ± 6.9

1.00

− 1.4 ± 5.9

0.82

0.9 ± 0.8

0.34

− 0.6 ± 5.7

0.92

Biopsy point

Point 1 (Comparison object)

0.0

–

0.0

–

0.0

–

0.0

–

0.0

–

0.0

–

0.0

–

Point 2

− 3.4 ± 1.1

 < 0.01

21.5 ± 6.9

 < 0.01

− 14.9 ± 2.9

 < 0.01

9.3 ± 6.0

0.12

26.3 ± 6.0

 < 0.01

− 2.4 ± 1.0

0.01

6.9 ± 6.1

0.25

Point 3

− 3.4 ± 1.1

 < 0.01

8.5 ± 6.9

0.21

− 13.2 ± 2.9

 < 0.01

22.0 ± 6.0

 < 0.01

23.8 ± 6.0

 < 0.01

− 3.3 ± 1.0

 < 0.01

16.8 ± 5.9

 < 0.01

Point 4

− 3.6 ± 1.1

 < 0.01

3.3 ± 6.9

0.62

− 14.9 ± 2.9

 < 0.01

10.4 ± 6.0

0.09

9.7 ± 6.0

0.11

− 3.5 ± 1.0

 < 0.01

20.9 ± 5.9

 < 0.01

Interaction terms (treatment and biopsy point)

Differences between treatment groups for changes between points 1 and 2

− 0.7 ± 1.5

0.66

− 16.1 ± 9.3

0.08

6.6 ± 4.0

0.09

− 4.1 ± 8.2

0.62

− 2.9 ± 8.2

0.72

− 1.8 ± 1.3

0.18

0.2 ± 8.2

0.98

Differences between treatment groups for changes between points 1 and 3

− 0.3 ± 1.5

0.84

16.6 ± 9.2

0.07

6.4 ± 4.0

0.11

8.4 ± 8.2

0.31

11.7 ± 8.2

0.15

− 1.3 ± 1.3

0.33

2.8 ± 8.1

0.73

Differences between treatment groups for changes between points 1 and 4

0.2 ± 1.5

0.89

8.0 ± 9.2

0.39

8.9 ± 4.0

0.02

10.3 ± 8.2

0.21

9.6 ± 8.2

0.24

− 0.4 ± 1.3

0.77

− 9.3 ± 8.1

0.25

Differences in expression levels between treatment groups at biopsy points

Point 3

0.0 ± 1.1

0.98

0.0 ± 1.1

 < 0.01

− 0.2 ± 2.8

0.95

8.4 ± 6.9

0.22

10.4 ± 5.9

0.08

− 0.4 ± 1.0

0.71

2.2 ± 5.7

0.70

Point 4

0.5 ± 1.1

0.67

0.5 ± 1.1

0.11

2.4 ± 2.8

0.40

10.3 ± 6.9

0.14

8.2 ± 5.9

0.17

0.5 ± 1.0

0.58

− 9.9 ± 5.7

0.08