Dosimetric and clinical analysis of pseudo-progression versus recurrence after hypo-fractionated radiotherapy for brain metastases

Table 3 Logistic regression screening for variables associated with the occurrence of tumor recurrence after hyper-fractionated radiotherapy in patients with brain metastases

Variables	Original database			Bootstrap repeated sampling (n = 1000)
Variables	OR	95% CI	P	Standard error	95% CI	P (bilateral)
GTV (cc)
< 6	1			1
6–28	1.65	0.70–3.87	0.251	0.62	− 0.94–1.46	0.694
≥ 28	0.12	0.11–1.26	0.077	9.72	− 23.13–0.26	0.041
BED (Gy)
< 60	1			1
60–73	0.13	0.01–1.72	0.120	11.30	− 24.13 –18.61	0.027
≥ 73	0.39	0.00–0.59	0.019	11.26	− 25.93–16.95	0.003
TC
≥ 0.96 vs. < 0.96	0.32	0.13–0.77	0.011	0.63	− 2.78 to − 0.23	0.013
Dose dropping zone Dmean (Gy)
≥ 77 vs. < 77	2.34	0.92–5.99	0.075	0.66	− 0.15–2.44	0.090
Target therapy
Yes vs. No	0.30	0.12–0.72	0.007	0.62	− 2.61 to − 0.12	0.028

GTV gross tumor volume, BED biological equivalent dose, TC target coverage, Dmean the mean dose, OR odds ratio, CI confidence interval

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