A retrospective study of adjuvant proton radiotherapy for breast cancer after lumpectomy: a comparison of conventional-dose and hypofractionated dose

Table 4 Comparison of normal tissue dose between our center and other center

	Our center	Sagar A. Patel (2017)		Mirjam E. MAST (2014)				Anna M. Flejimer (2015)			Carmen Ares (2010)			John J. Cuaron
	IMPT	Photon	Proton	IMPT-BH	IMRT-BH	MRT-FB	MPT-FB	Photon with gating	Phton-fb	IMPT	3D-RT	IMRT	IMPT	Proton
Ipsilateral lungipsilateral lung
V5	30.72 ± 9.95%			7.1 ± 2.7%	21.4 ± 6.6%	21.9 ± 7.1%	7.7 ± 2.7%				27 ± 3%	46 ± 12%	17 ± 7%	4.35(22.5–53.8)
V10	23.38 ± 8.49%							21.5 ± 10.0%	23.3 ± 13.2%	21.1 ± 4.4%
V20	13.41 ± 5.91%	26.04 ± 4.30%	15.18 ± 3.66%	2.5 ± 1.4%	10.9 ± 4.7%	12.4 ± 5.7%	2.8 ± 1.4%	16.4 ± 8.1%	18.2 ± 10.9%	9.4 ± 1.8%	14 ± 3%	9 ± 1%	7 ± 4%	16.5(6.1–30.3)
Dmean	6.61 ± 2.52 Gy	13.30 ± 1.70 Gy	7.63 ± 1.27 Gy	1.5 ± 0.6 Gy	5.4 ± 1.8 Gy	6.1 ± 2.3 Gy	1.6 ± 0.6 Gy	9.0 ± 3.9 Gy	9.7 ± 5.1 Gy	5.5 ± 1.1 Gy	17 ± 2 Gy	15 ± 2 Gy	7 ± 3 Gy
Heart (left breast cancer)
D2%	15.40 ± 9.90 Gy							11.0 ± 12.1 Gy	25.4 ± 15.4 Gy	6.0 ± 3.8 Gy
V5	4.74 ± 2.87%			0.1 ± 0.2%	2.5 ± 2.1%	7.4 ± 4.7%	0.5 ± 0.8%	3.7 ± 3.7%	7.6 ± 4.2%	2.4 ± 1.6%	10 ± 7%	42 ± 9%	2 ± 2%	0.00(0.17–14.40)
V20	1.63 ± 0.85%	1.97 ± 4.40%	0.86 ± 0.68%	0	0.6 ± 0.8%	3.5 ± 3.0%	0.1 ± 0.2%	0.9 ± 1.5%	3.1 ± 2.4%	0.2 ± 0.3%	4 ± 4%	3 ± 2%	0 ± 1%	1.16(0–6.0)
Dmean	0.98 ± 0.63 Gy	2.09 ± 1.48 Gy	0.98 ± 0.66 Gy	0.1 ± 0 Gy	1.5 ± 0.5 Gy	2.7 ± 1.3 Gy	0.2 ± 0.1 Gy	1.6 ± 0.8 Gy	2.7 ± 1.2 Gy	0.4 ± 0.3 Gy	9 ± 4 Gy	12 ± 2 Gy	1 ± 1 Gy	1.0(0.09–3.20)
LAD (left anterior descending artery)
D2%	28.59 ± 11.05 Gy							21.9 ± 16.1 Gy	41.8 ± 8.4 Gy	12.8 ± 3.0 Gy
Dmean	4.86 ± 2.42 Gy			0.3 ± 0.2 Gy	6.7 ± 5.1 Gy	14.9 ± 9.3 Gy	0.7 ± 0.8 Gy	9.7 ± 9.6 Gy	22.0 ± 11.7 Gy	4.0 ± 0.9 Gy

IMPT intensity-modulated proton therapy; BH breath hold; FB free breathing; IMRT intensity modulated radiation therapy

ISSN: 1748-717X