Table 3 Subgroup analysis of prognostic factors by univariate analysis
Factor | Number | LPFS | OS | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Median (month) | 1-year (%) | 2-year (%) | 3-year (%) | P value | Median (month) | 1-year (%) | 2-year (%) | 3-year (%) | P value | ||
Age (years) | 0.322 | 0.228 | |||||||||
< 63 | 59 | 11.23 | 48.7 | 26.1 | 19.9 | 19.67 | 81.4 | 38.9 | 32.7 | ||
≥ 63 | 67 | 11.0 | 48.9 | 20.1 | 12.1 | 19.9 | 79.1 | 38.6 | 17.2 | ||
KPS | 0.023 | 0.129 | |||||||||
≤ 80 | 52 | 10.17 | 37.9 | 11.4 | 6.8 | 18.88 | 78.8 | 32.2 | 15.6 | ||
≥ 90 | 74 | 13.0 | 56.5 | 31.1 | 22.2 | 19.98 | 81.1 | 43.2 | 30.6 | ||
Initial tumor stage | 0.296 | 0.305 | |||||||||
I–II | 45 | 10.13 | 44.0 | 18.5 | 9.7 | 18.37 | 77.8 | 31.1 | 21.8 | ||
III–IVA | 81 | 11.93 | 51.4 | 25.5 | 19.5 | 19.97 | 81.5 | 43.1 | 25.4 | ||
No. of recurrent lymph nodes | 0.795 | 0.389 | |||||||||
Single | 48 | 11.92 | 51.6 | 23.6 | 12.9 | 19.82 | 79.2 | 41.7 | 31.0 | ||
Multiple | 78 | 10.85 | 47.1 | 22.7 | 17.6 | 19.52 | 80.8 | 36.9 | 19.9 | ||
Boundary of recurrent lymph nodes | 0.565 | 0.838 | |||||||||
Clear | 95 | 11.17 | 48.8 | 19.7 | 14.8 | 19.97 | 83.2 | 37.7 | 23.9 | ||
Non-clear | 31 | 11.23 | 48.4 | 32.3 | 17.4 | 16.13 | 71.0 | 41.9 | 24.3 | ||
Lesion volume (cm3) | 0.165 | 0.059 | |||||||||
< 22.2 | 61 | 13.47 | 55.5 | 27.8 | 18.2 | 22.23 | 82.0 | 45.9 | 30.1 | ||
≥ 22.2 | 65 | 10.9 | 42.6 | 18.6 | 13.5 | 18.37 | 78.5 | 32.1 | 19.0 | ||
Prescribed dose (Gy) | 0.6 | 0.525 | |||||||||
≤ 120 | 70 | 10.28 | 45.2 | 18.1 | 16.1 | 19.47 | 77.1 | 35.7 | 22.5 | ||
> 120 | 56 | 13.03 | 53.2 | 29.1 | 15.2 | 20.15 | 83.9 | 42.7 | 27.3 | ||
D90 (Gy) | 0.178 | 0.886 | |||||||||
≤ 130.3 | 62 | 10.62 | 51.1 | 29.7 | 23.3 | 19.83 | 79.0 | 41.8 | 25.7 | ||
> 130.3 | 64 | 11.45 | 56.3 | 17.2 | 12.5 | 19.67 | 81.3 | 35.9 | 23.0 | ||
Time interval between RT and Iodine-125 seed implantation (months) | 0.42 | 0.326 | |||||||||
≤ 13 | 67 | 11.23 | 47.5 | 22.7 | 12.7 | 18.97 | 79.1 | 34.1 | 22.1 | ||
> 13 | 59 | 11.0 | 50.3 | 23.4 | 19.2 | 21.67 | 81.4 | 44.0 | 27.4 | ||
Seed activity (mCi) | 0.561 | 0.219 | |||||||||
≤ 0.6 | 75 | 11.23 | 48.8 | 26.2 | 16.3 | 20.3 | 86.7 | 42.4 | 27.8 | ||
> 0.6 | 51 | 11.0 | 48.8 | 18.3 | 15.3 | 17.23 | 70.6 | 33.3 | 19.7 | ||
Short-term efficacy | 0.026 | 0.011 | |||||||||
CR + PR | 88 | 14.32 | 56.6 | 25.7 | 20.0 | 21.1 | 86.4 | 43.0 | 27.6 | ||
SD + PD | 38 | 9.05 | 30.7 | 16.7 | 8.4 | 14.52 | 65.8 | 28.9 | 16.9 | ||