Functional brain imaging interventions for radiation therapy planning in patients with glioblastoma: a systematic review

Ryan, John T; Nakayama, Masao; Gleeson, Ian; Mannion, Liam; Geso, Moshi; Kelly, Jennifer; Ng, Sweet Ping; Hardcastle, Nicholas

doi:10.1186/s13014-022-02146-8

Table 2 Target volume outcomes

From: Functional brain imaging interventions for radiation therapy planning in patients with glioblastoma: a systematic review

Study name	Citations	Functional imaging agent	Intervention aim							Treatment
			Improve standard RTtarget delineation	Facilitate doseescalation	Facilitate organ at risk sparing	Map recurrence & RT treated volumes	Map functional volumes& RT planning volumes	Map treated functionalvolumes & survival	Map radiomic features& RT volumes	Standard treatment	Standard targetvolumes changed	Dose escalation
Niyazi	[32, 33]	F18-FET PET					\(\checkmark\)			\(\checkmark\)
Piroth	[34,35,36,37]	F18-FET PET		\(\checkmark\)		\(\checkmark\)		\(\checkmark\)			\(\checkmark\)	\(\checkmark\)
Munck Af Rosenschold	[40, 41]	F18-FET PET	\(\checkmark\)				\(\checkmark\)	\(\checkmark\)			\(\checkmark\)
Lundemann	[42,43,44]	F18-FET PET	\(\checkmark\)			\(\checkmark\)	\(\checkmark\)		\(\checkmark\)		\(\checkmark\)
Poulsen	[45, 46]	F18-FET PET	\(\checkmark\)					\(\checkmark\)			\(\checkmark\)
Harat	[47]	F18-FET PET				\(\checkmark\)	\(\checkmark\)			\(\checkmark\)
Hayes	[48]	F18-FET PET	\(\checkmark\)			\(\checkmark\)	\(\checkmark\)				\(\checkmark\)
Fleischmann	[49]	F18-FET PET				\(\checkmark\)	\(\checkmark\)			\(\checkmark\)
Hirata	[54, 55]	C11-MET & F18-FDG PET				\(\checkmark\)	\(\checkmark\)	\(\checkmark\)		\(\checkmark\)
Christensen	[57]	C11-AMT PET				\(\checkmark\)	\(\checkmark\)			\(\checkmark\)
Kosztyla	[58]	F18-FDOPA PET				\(\checkmark\)	\(\checkmark\)			\(\checkmark\)
Windisch	[62, 63]	FAP PET					\(\checkmark\)			\(\checkmark\)
Munshi	[64]	DCE MRI					\(\checkmark\)			\(\checkmark\)
Wahl	[65]	DW & DCE MRI				\(\checkmark\)	\(\checkmark\)	\(\checkmark\)		\(\checkmark\)
Berberat	[69]	DTI MRI				\(\checkmark\)	\(\checkmark\)			\(\checkmark\)
Altabella	[72]	DTI MRI			\(\checkmark\)					\(\checkmark\)
Peeken	[73]	DTI MRI				\(\checkmark\)	\(\checkmark\)		\(\checkmark\)	\(\checkmark\)
Morin	[74]	DW MRI	\(\checkmark\)			\(\checkmark\)	\(\checkmark\)			\(\checkmark\)
Laprie	[77,78,79,80]	MRSI		\(\checkmark\)								\(\checkmark\)
Gurbani	[84]	MRSI				\(\checkmark\)	\(\checkmark\)					\(\checkmark\)

Study name	RT target volume details
Study name	GTV-S (cm\(^3\))	GTV-F (cm\(^3\))	GTV-S+F (cm\(^3\))	CTV-S (cm\(^3\))	CTV-F (cm\(^3\))	CTV-S+F (cm\(^3\))	PTV-S (cm\(^3\))	PTV-F (cm\(^3\))	PTV-S+F (cm\(^3\))	CTV Target change (%)	PTV Target change (%)	Boost Volume (cm\(^3\))
Niyazi	x 34.1	x 43.9	x 48	x 224.5	x 240.3	x 286.8	x 343.5	x 356.5	x 416.5	x +27.7	x +21.1
Piroth	\(\bar{x}\) 5.2	\(\bar{x}\) 14.3					\(\bar{x}\) 219.5					\(\bar{x}\) 14.3
Munck Af Rosenschold	x 37	x 19.8	x 38.2	\(\bar{x}\) 275	\(\bar{x}\) 290	\(\bar{x}\) 300				\(\bar{x}\) +9.1
Lundemann	x 33.8	x 21.4	x 41.6
Poulsen		x 21.8
Harat		x 30.4
Hayes				x 83.6		x 94.7				x +13.3
Fleischmann	x 14.0	x 19.8	x 30.8				x 297.8		x 271.3		x \(-\)8.9
Hirata	x 9.9	x 60.4	x 60.4
Christensen	\(\bar{x}\) 50.2	\(\bar{x}\) 48.9	\(\bar{x}\) 67.6
Kosztyla	\(\bar{x}\) 30.8	\(\bar{x}\) 58.6	\(\bar{x}\) 63.5	\(\bar{x}\) 249	\(\bar{x}\) 306	\(\bar{x}\) 312	\(\bar{x}\) 369	\(\bar{x}\) 437	\(\bar{x}\) 445	\(\bar{x}\) +25.3	\(\bar{x}\) +20.6
Windisch	x 33.8	x 23.8 - 49.6	x 60.8				x 271
Munshi	x 40.8	x 17.2	x 46.3	x 200.1		x 221.0	x 258		x 286	x +10.4	x +10.8
Wahl	\(\bar{x}\) 37.8	\(\bar{x}\) 21.4
Berberat										\(-\)50	\(-\)15
Altabella							\(\bar{x}\) 543
Peeken	x 23.3	x 5.9		x 207.2\(^\alpha\) - 276.8\(^\beta\)		x 240.9				x -13.0 - +16.3
Morin										x -26.7
Laprie									x 307.8			x 97.63
Gurbani		50.6										\(\le\) 65

S Standard contouring, F Functional imaging used, S+F= combined, x = Median, \(\bar{x}\) = Mean, \(\alpha\) = EORTC guidelines, \(\beta\) = RTOG guidelines

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