Table 1 Clinical, laboratory and pathological features of the 47-Brazilian patients with PCNSL
Characteristic | N = 47 (N, %) |
|---|---|
Median age (years) | 59.8(24.9–88.1) |
Male gender | 25 (53.1) |
Caucasian | 36 (76.6) |
LDH ≥ UVN | 21 (44.7) |
β2-microglobulin ≥ UVN | 29 (62.1) |
Albumin < 3.5 g/dL | 09 (19.2) |
ECOG ≥ 2 | 32 67.6 |
Karnofsky < 70 | 18 (38.3) |
Multifocal disease | 16 (34.1) |
CSF with positive oncotic citology | 09 (19.2) |
Clinical Hemiparesis or hemiplegia Seizures Confusional state Cranial nerve impairment | 23 (55.3) 05 (10.6) 15 (31.9) 01 (2.2) |
Deep brain involvement | 21 (44.7) |
CSF protein > 40 mg/dL | 29 (61.7) |
Prognostic scores intermediate and high-risk IELSG MSKCC Nottinghan/Barcelona | 24 (51) 19 (40.4) 17 (36.1) |
Anemia | 09 (19.2) |
Neutrophilia | 18 (38.3) |
Lymphopenia | 03 (6.3) |
Monocytosis | 01 (2.2) |
Thrombocytopenia | 0 (0) |
GC-like subtype | 14/33 (42.4) |
non-GC subtype | 19/33 (57.6) |