Table 2 Factors associated with salvage treatments after first surgery without adjuvant radiotherapy

Total (% out of 216)

125 (58%)

56 (26%)

35 (16%)

Gender

 Female (%)

56 (45%)

23 (41%)

16 (46%)

p = 0.87

 Male (%)

69 (55%)

33 (59%)

19 (54%)

Mean age at first surgery

Years

57.2

50.1

59.3

p = 2.10⁻³ (S vs. S–S)

p = 0.4 (S vs. S–sRT)

p = 10⁻³ (S–S vs. S–sRT)

Visual disorders

 No

48 (41%)

16 (32%)

9 (27%)

p = 0.27 (S vs. S–S)

 Yes

69 (59%)

34 (68%)

24 (73%)

p = 0.15 (S vs. S–sRT)

 Unknown

8

6

2

p = 0.64 (S–S vs. S–sRT)

Cavernous sinus invasion

 No

87 (74%)

12 (39%)

6 (25%)

p < 10⁻³ (S vs. S–S)

 Yes

30 (26%)

19 (61%)

18 (75%)

p < 10⁻⁵ (S vs. S–sRT)

 Unknown

8

25

11

p = 0.28 (S–S vs. S–sRT)

Tumor type

 Nude cells

40 (37%)

20 (45%)

14 (44%)

p = NS

 ACTH

5 (5%)

3 (7%)

1 (3%)

 FSH/LH

62 (57%)

21 (48%)

17 (53%)

 GH

0

0

0

 PRL

1 (1%)

0

0

 TSH

1 (1%)

0

0

Residual tumor after first surgery

 No

26 (22%)

3 (6%)

0 (0%)

p < 0.05 (S vs. S–S)

 Yes

92 (78%)

45 (94%)

31 (100%)

p = 4.10⁻³ (S vs. S–sRT)

 Unknown

7

8

4

p = 0.16 (S–S vs. S–sRT)

Mean duration between first surgery and salvage treatment

 Years

NA

6.6

5.4

p = 0.23