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Table 1 OAR constraint and target volume metrics are presented for the initial non adaptive (PI) and adapted (PA) plans

From: The first reported case of a patient with pancreatic cancer treated with cone beam computed tomography-guided stereotactic adaptive radiotherapy (CT-STAR)

Organ-at-risk

Strict constraint

PI mean (std dev)

PI median (range)

PA mean (std dev)

PA median (range)

Stomach

V25 Gy < 0.5 cc (cc)

10.2 (3.6)

9.7 (5.6–14.8)

0.0 (0.1)

0.0 (0.0–0.1)

Duodenum

V25 Gy < 0.5 cc (cc)

0.1 (0.1)

0.1 (0.0–0.2)

0.0 (0.0)

0.0 (0.0–0.0)

Small bowel

V25 Gy < 0.5 cc (cc)

3.8 (5.1)

1.2 (0.3–13.8)

0.0 (0.0)

0.0 (0.0–0.1)

Large bowel

V25 Gy < 0.5 cc (cc)

0.0 (0.0)

0.0 (0.0–0.1)

0.1 (0.1)

0.0 (0.0–0.2)

Liver

V25 Gy < 33% (%)

9.5 (1.6)

10.1 (6.8–11.4)

12.1 (1.8)

11.0 (10.3–14.7)

700 cc < 20 Gy (Gy)

0.4 (.1)

0.3 (0.2–0.6)

0.4 (0.1)

0.4 (0.3–0.5)

Mean < 20 Gy (Gy)

1.0 (0.2)

1.0 (0.8–1.2)

1.2 (0.1)

1.2 (1.0–1.3)

Spinal cord

V25 Gy < 0.5 cc (cc)

0.0 (0.0)

0.0 (0.0–0.0)

0.0 (0.0)

0.0 (0.0–0.0)

Kidneys (both)

Mean < 18 Gy (Gy)

0.8 (0.7)

0.8 (0.7–0.9)

0.8 (0.1)

0.8 (0.7–0.9)

Target volume

Coverage goal

PI mean (std dev)

PI median (range)

PA mean (std dev)

PA median (range)

PTV V100

N/A (%)

77.1 (2.1)

76.0 (74.5–80.0)

77.8 (5.1)

80.8 (67.9–81.3)

PTV D95

N/A (Gy)

4.7 (0.1)

4.6 (4.6–4.9)

4.8 (0.1)

4.8 (4.6–5.0)

PTVopt

95% (%)

83.5 (3.8)

83.5 (78.8–91.4)

99.6 (0.3)

99.5 (99.2–100.1)

GTV V100

N/A (%)

89.9 (1.1)

90.0 (88.5–91.4)

90.0 (4.0)

91.8 (82.2–93)

GTV D95

N/A (Gy)

6.0 (0.2)

6.1 (5.6–6.3)

6.4 (0.3)

6.5 (5.7–6.7)

  1. Mean and median constraint and target metrics for the PI represent the hypothetical use of the PI applied to all five fractions
  2. N/A not applicable, Std Dev standard deviation