Palliative radiotherapy of bone metastases in octogenarians: How do the oldest olds respond? Results from a tertiary cancer center with 288 treated patients

Table 4 Univariate and multivariate Cox analysis of several parameters regarding OS in octogenarians receiving palliative radiotherapy for bone metastases (n = 288)

	HR	95% CI	p value
Univariate analysis
Age (continuous)	1.017	0.973–1.063	0.456
ECOG (continuous)	1.641	1.398–1.927	< 0.001
Gender (reference: female)	1.483	1.156–1.903	0.002
Systemic treatment (reference: systemic treatment)	0.887	0.676–1.165	0.390
Primary cancer (reference: genitourinary)	1.038	0.810–1.329	0.770
Primary cancer (reference: breast)	1.914	1.423–2.576	< 0.001
Mizumoto score (continuous)	1.164	1.080–1.255	< 0.001
SINS (continuous)	1.076	1.029–1.126	0.001
Multivariate analysis
ECOG (continuous)	1.411	1.174–1.695	< 0.001
Gender (reference: female)	0.731	0.473–1.130	0.159
Primary cancer (reference: breast)	1.578	0.934–2.667	0.088
Mizumoto score (continuous)	1.127	1.040–1.222	0.004
SINS (continuous)	1.100	1.047–1.155	< 0.001

Significant p values (< 0.05) are expressed in bold
ECOG Eastern Cooperative Oncology Group, SINS Spinal Instability Neoplastic Score
Pre-therapeutic parameters which exhibited a p value < 0.1 in the univariate analysis were included in the multivariate analysis. In the multivariate analysis, all variables were entered in the model in one single step (enter method). Hazard ratios (HRs) and the corresponding 95% confidence intervals (95% CI) are shown

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