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Table 4 Associations between investigated factors and maintainance of ambulatory status after treatment

From: Identifying patients with malignant spinal cord compression (MSCC) near end of life who can benefit from palliative radiotherapy

Factor

Subgroup (n)

Maintaining ambulatory status, n (%)

p value

Age

 ≤ 65 years (85)

60 (71)

0.74

 > 65 years (85)

58 (68)

Interval FD to MSCC

 ≤ 15 months (122)

84 (69)

0.80

 > 15 months (48)

34 (71)

Visceral metastases

No (24)

20 (83)

0.15

Yes (146)

98 (67)

Further bone metastases

No (48)

31 (65)

0.39

Yes (122)

87 (71)

Primary tumor type

Breast cancer (26)

15 (58)

0.069

Prostate cancer (13)

6 (46)

Myeloma/lymphoma (9)

8 (89)

Lung cancer (59)

46 (78)

Other malignancies (63)

43 (68)

Sex

Female (58)

39 (67)

0.66

Male (112)

79 (71)

Time developing motor deficits

0–7 days (58)

33 (57)

< 0.001

8–14 days (51)

32 (63)

 > 14 days (61)

53 (87)

ECOG performance score

1–2 (69)

59 (86)

< 0.001

3–4 (101)

59 (58)

Number of affected vertebrae

1–2 (79)

58 (73)

0.29

 ≥ 3 (91)

60 (66)

Radiotherapy regimen

1 × 8 Gy/5 × 4 Gy (71)

50 (70)

0.81

5 × 5 Gy/Longer-course RT (99)

68 (69)

Entire cohort

N = 170

118 (69)

 
  1. FD First diagnosis of malignancy, MSCC Metastatic spinal cord compression, ECOG Eastern Cooperative Oncology Group, RT Radiotherapy
  2. p values were calculated with the Chi-square test or the Fisher’s exact test (for n < 5). When applying Bonferroni adjustment, p values of < 0.005 were considered significant and are given in bold