Table 1 Associations between investigated factors and successful treatment (improved motor function or remaining ambulatory without aid)
Factor | Subgroup (n) | Successful treatment, n (%) | p value |
|---|---|---|---|
Age | ≤ 65 years (275) | 35 (13) | 0.47 |
> 65 years (270) | 29 (11) | ||
Interval FD to MSCC | ≤ 15 months (383) | 42 (11) | 0.39 |
> 15 months (162) | 22 (14) | ||
Visceral metastases | No (114) | 19 (17) | 0.066 |
Yes (431) | 45 (10) | ||
Further bone metastases | No (126) | 13 (10) | 0.57 |
Yes (419) | 51 (12) | ||
Primary tumor type | Breast cancer (57) | 6 (11) | < 0.0001 |
Prostate cancer (74) | 6 (8) | ||
Myeloma/lymphoma (24) | 10 (42) | ||
Lung cancer (175) | 25 (14) | ||
Other malignancies (215) | 17 (8) | ||
Sex | Female (170) | 21 (12) | 0.77 |
Male (375) | 43 (11) | ||
Time developing motor deficits | 0–7 days (309) | 16 (5) | < 0.0001 |
8–14 days (122) | 14 (11) | ||
> 14 days (114) | 34 (30) | ||
Ambulatory prior to radiotherapy | No (375) | 28 (7) | < 0.0001 |
Yes (170) | 36 (21) | ||
Number of affected vertebrae | 1–2 (192) | 35 (18) | < 0.001 |
≥ 3 (353) | 29 (8) | ||
Radiotherapy regimen | 1 × 8 Gy/5 × 4 Gy (239) | 22 (9) | 0.10 |
5 × 5 Gy/longer-course RT (306) | 42 (14) | ||
Entire cohort | N = 545 | 64 (12) |