From: A retrospective study comparing definitive chemoradiotherapy vs. chemoradiotherapy followed by surgery in T4 esophageal squamous cell carcinoma patients who were downstaged after neochemoradiotherapy
Type of first progression
CRT-S (n = 32)
D-CRT (n = 74)
P
Local recurrence
1
27
 < 0.001
Regional lymph node metastasis
6
19
Distant metastasis
8
12
Stable
17
16