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Table 2 Baseline clinicopathological characteristics of the training set of RT alone for elderly NPC patients

From: Selection and validation of chemotherapy beneficiaries among elderly nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT): a large real-world study

Characteristics

Train set in RT alone (N = 310) (%)

Univariate analysis of OS

Multivariate analysis of OS

HR (95% CI)

*P

aHR (95% CI)

*P

Gender

 Male

227 (73.2)

Reference

   

 Female

83 (26.8)

0.946 (0.569, 1.571)

0.829

–

–

Age at diagnosis, years

 60–64

100 (32.3)

Reference

Reference

  

 65–69

97 (31.3)

1.632 (0.905, 2.946)

0.104

0.015 (0.541, 1.903)

0.963

 ≥ 70

113 (36.5)

1.870 (1.084, 3.226)

0.024

0.115 (0.619, 2.035)

0.704

Histological type

 WHO type I–II

8 (2.6)

Reference

   

 WHO type III

302 (97.4)

2.403 (0.333, 17.315)

0.384

–

–

Family history of cancer

 No

223 (71.9)

Reference

   

 Yes

87 (28.1)

1.5 (0.941, 2.391)

0.089

–

–

ACE-27, scores

 0

136 (43.9)

Reference

   

 1

122 (39.4)

0.824 (0.498, 1.363)

0.451

–

–

 2–3

52 (16.8)

1.662 (0.939, 2.942)

0.081

–

–

Smoking

 No

214 (69.0)

Reference

   

 Yes

96 (31.0)

0.968 (0.606, 1.547)

0.892

–

–

Alcohol consumption

 No

278 (89.7)

Reference

   

 Yes

32 (10.3)

0.422 (0.154, 1.154)

0.093

–

–

#Plasma EBV DNA titer, copies/mL

  ≤ 4000

239 (77.1)

Reference

Reference

  

  > 4000

71 (22.9)

3.694 (2.335, 5.845)

 < 0.001

1.078 (1.747, 4.944)

 < 0.001

#$Hb, g/L

  < 120.0 (110.0)

21 (6.8)

1.557 (0.714, 3.398)

0.266

–

–

  ≥ 120.0 (110.0)

289 (93.2)

Reference

   

#Albumin, g/L

  < 40.0

36 (11.6)

2.381 (1.35, 4.2)

0.003

0.316 (0.751, 2.506)

0.304

  ≥ 40.0

274 (88.4)

Reference

Reference

  

#LDH, U/L

     

  ≤ 250

293 (94.5)

Reference

Reference

  

  > 250

17 (5.5)

2.492 (1.193, 5.205)

0.015

1.254 (1.657, 7.406)

0.001

#CRP, mg/L

  ≤ 3.00

241 (77.7)

Reference

   

  > 3.00

69 (22.3)

1.119 (0.669, 1.873)

0.668

–

–

T category

 T1–2

150 (48.4)

Reference

Reference

  

 T3–4

160 (51.6)

2.586 (1.614, 4.143)

 < 0.001

0.724 (1.217, 3.496)

0.007

N category

 N0–1

242 (78.1)

Reference

Reference

  

 N2–3

68 (21.9)

1.77 (1.078, 2.905)

0.024

0.047 (0.614, 1.788)

0.863

  1. Variables with statistical differences are in bold
  2. T and N category were determined based on the 8th edition of American Joint Committee on Cancer/International Union Against Cancer staging system. Hb, albumin, LDH, and CRP were converted into categorical variables based on clinical cut-off values
  3. Plasma EBV DNA plasma Epstein–Barr virus DNA, NPC nasopharyngeal carcinoma, WHO World Health Organization, ACE-27 Adult Comorbidity Evaluation 27, Hb hemoglobin, LDH serum lactate dehydrogenase, CRP C-reactive protein, OS overall survival, HR hazard ratio, aHR adjusted hazard ratio, 95% CI 95% confidence interval
  4. #All of these variables were measured before treatment
  5. $Cut-off values of Hb are 120 and 110 g/L for male and female, respectively
  6. *P values were calculated with univariate Cox proportional-hazards model
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Radiation Oncology

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