An interpretable radiomics model to select patients for radiotherapy after surgery for WHO grade 2 meningiomas

Radiation Oncology

Table 1 Patient characteristics in the training and test sets

Clinical variables	Training set (n = 92)		P-value^a	Test set (n = 63)		P-value^a	P-value^b
	Without tumor recurrence	With tumor recurrence		Without tumor recurrence	With tumor recurrence
	(n = 80)	(n = 12)		(n = 54)	(n = 9)
Age (years)	57.3 ± 14.6	54.4 ± 13.6	0.530	55.7 ± 14.1	67.7 ± 13.2	0.020	0.838
Female ratio	52 (65.0%)	9 (75.0%)	0.494	38 (70.4%)	3 (33.3%)	0.031	0.875
Extent of resection			0.011			0.045	0.535
GTR	70 (87.5%)	7 (58.3%)		49 (90.7%)	6 (66.7%)
STR	10 (12.5%)	5 (41.7%)		5 (9.3%)	3 (33.3%)
Ki-67 labeling index	6.03 ± 4.81	6.96 ± 2.73	0.515	5.9 ± 4.3	8.2 ± 3.1	0.131	0.874
< 5%	32 (40.0%)	3 (25.0%)	0.076	29 (53.7%)	1 (11.1%)	0.018
≥ 5%	38 (47.5%)	9 (75.0%)		25 (46.3%)	8 (88.9%)
ART			0.659			0.517	0.595
Performed	48 (60.0%)	8 (66.7%)		36 (66.7%)	5 (55.6%)
Not performed	32 (40.0%)	4 (33.3%)		18 (33.3%)	4 (44.4%)
ART modality^c			0.851			0.061	0.813
3D-CRT	5 (10.4%)	2 (25.0%)		2 (5.6%)	2 (40.0%)
IMRT	43 (89.6%)	6 (75.0%)		34 (94.4%)	3 (60.0%)
ART dose (Gy)^c	57.3 ± 4.0	57.2 ± 6.7	0.956	58.3 ± 3.9	58.7 ± 2.6	0.853	0.204

Data are expressed as the mean with standard deviation in parentheses, median with interquartile range in parentheses, or number with percentage in parentheses
^aCalculated from Student’s-t test for continuous variables and Chi-square test for categorical variables to compare the patient characteristics between the responder and non-responders from each training and test set
^bCalculated from Student’s-t test for continuous variables and Chi-square test for categorical variables for the comparison of training and test sets
^cData obtained from patients who underwent adjuvant radiotherapy following surgery
GTR: gross total resection; STR: subtotal resection; ART: adjuvant radiotherapy; RT: radiotherapy; 3D-CRT: three-dimensional conformal radiotherapy; IMRT: intensity modulated radiotherapy

ISSN: 1748-717X