Table 3 Univariate and multivariate prognostic analyses of BCSS in all patients
Characteristics | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
HR | 95%CI | P | aHR | 95%CI | P | |
Treatment groups | ||||||
Non-RT | 1.00 | 1.00 | ||||
RT | 0.51 | 0.39–0.66 | < 0.001 | 0.64 | 0.49–0.83 | 0.001 |
Age of diagnosis, years | ||||||
< 50 | 1.00 | 1.00 | ||||
50–59 | 1.08 | 0.58–2.03 | 0.803 | 1.11 | 0.59–2.10 | 0.746 |
60–69 | 1.46 | 0.83–2.57 | 0.192 | 1.51 | 0.84–2.68 | 0.166 |
≥ 70 | 3.51 | 2.12–5.80 | < 0.001 | 3.05 | 1.80–5.17 | < 0.001 |
Era of diagnosis | ||||||
1998–2004 | 1.00 | |||||
2005–2009 | 1.04 | 0.77–1.41 | 0.789 | |||
2010–2015 | 0.88 | 0.55–1.41 | 0.606 | |||
Race | ||||||
White | 1.00 | 1.00 | ||||
Black | 1.49 | 1.00–2.22 | 0.047 | 1.44 | 0.96–2.15 | 0.076 |
Other | 0.52 | 0.30–0.91 | 0.022 | 0.70 | 0.39–1.20 | 0.213 |
Marital status | ||||||
Married | 1.00 | 1.00 | ||||
Non-married | 0.92 | 0.56–1.51 | 0.736 | 0.98 | 0.59–1.61 | 0.931 |
DSW | 2.25 | 1.71–2.96 | < .001 | 1.56 | 1.17–2.08 | 0.002 |
Unknown | 1.90 | 1.02–3.55 | 0.045 | 1.36 | 0.72–2.56 | 0.339 |
Laterality | ||||||
Left | 1.00 | |||||
Right | 0.95 | 0.74–1.23 | 0.690 | |||
Tumor size (T stage), cm | ||||||
≤ 1.0 (T1) | 1.00 | 1.00 | ||||
1.1–2.0 (T1) | 1.85 | 1.35–2.53 | < 0.001 | 1.92 | 1.40–2.63 | < .001 |
2.1–3.0 (T2) | 2.95 | 2.05–4.24 | < 0.001 | 3.02 | 2.09–4.36 | < .001 |
Tumor grade | ||||||
I | 1.00 | 1.00 | ||||
II | 1.35 | 1.00–1.82 | 0.049 | 1.31 | 0.97–1.77 | 0.079 |
III/IV | 1.95 | 1.05–3.63 | 0.034 | 1.91 | 1.02–3.59 | 0.043 |
unknown | 1.19 | 0.85–1.68 | 0.305 | 1.16 | 0.83–1.64 | 0.390 |
ER status | ||||||
Positive | 1.00 | |||||
Negative | 1.65 | 0.78–3.53 | 0.120 | |||
Unknown | 1.24 | 0.83–1.85 | 0.300 | |||
PR status | ||||||
Positive | 1.00 | 1.00 | ||||
Negative | 1.56 | 1.08–2.26 | 0.020 | 1.47 | 1.01–2.13 | 0.045 |
Unknown | 1.37 | 0.95–1.98 | 0.100 | 1.19 | 0.82–1.72 | 0.368 |
Chemotherapy | ||||||
No/Unknown | 1.00 | |||||
Yes | 0.75 | 0.46–1.21 | 0.460 | |||