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Table 1 Patient characteristics and treatment

From: Long-term survival of two patients with inoperable post-irradiation osteosarcoma treated with carbon-ion radiotherapy: a case report

 

Case 1

Case 2

Treatment for uterine cervical cancer

Purpose

Postoperative RT

Postoperative RT

Dose of prior RT

EBRT 50 Gy/25 fr.*

EBRT 50 Gy/25 fr.*

 

ICBT 7 Gy/1 fr

ICBT 24 Gy/4 fr

Chemotherapy for uterine cervical cancer

None

None

C-ion RT for post-irradiation osteosarcoma

Duration from prior RT to diagnosis of post-irradiation osteosarcoma, months

112.8

172.2

Age at registration of C-ion RT years

67

55

Tumor location

Left iliac bone

Sacral bone

Tumor size, mm

50 × 80 × 95

51 × 52 × 68

Staging

cT2bN0M0

cT2bN0M0

Histological analysis

Conventional osteosarcoma

Conventional osteosarcoma

Chemotherapy before C-ion RT

Methotrexate and vincristine

Methotrexate

 

Doxorubicin and cisplatin

Pirarubicin and cisplatin

 

Pazopanib

 

Dose of C-ion RT

70.4 Gy (RBE)/16 fr

70.4 Gy (RBE)/16 fr

Chemotherapy after C-ion RT

Pazopanib

Pazopanib

  

Methotrexate

  1. C-ion RT, carbon-ion radiotherapy; EBRT, external-beam radiotherapy; fr, fractions; ICBT, intracavitary brachytherapy; RBE, relative biological effectiveness; RT, radiotherapy
  2. *The last 20 Gy was delivered using a central shielding technique