Radiation Oncology

Table 5 Multivariate analyses with respect to factors and the risk of HT

From: Predictors of radiation-induced hypothyroidism in nasopharyngeal carcinoma survivors after intensity-modulated radiotherapy

Variable	Multivariate analyses
Variable	HR (95% CI)	p value
The VS45 Model
Age (per year increase)	0.979 (0.967–0.991)	0.001*
Female (vs male)	1.690 (1.231–2.319)	0.001*
Chemotherapy (vs no)	1.194 (0.758–1.881)	0.444
Thyrotoxicosis (vs no)	0.638 (0.459–0.887)	0.008*
Thyroid VS45 (per cm³ increase)	0.876 (0.833–0.920)	0.000*
The VS50 Model
Age (per year increase)	0.979 (0.967–0.992)	0.001*
Female (vs male)	1.658 (1.207–2.278)	0.002*
Chemotherapy (vs no)	1.284 (0.818–2.015)	0.277
Thyrotoxicosis (vs no)	0.656 (0.472–0.913)	0.012*
Thyroid VS50 (per cm³ increase)	0.883 (0.844–0.924)	0.000*
The VS55 Model
Age (per year increase)	0.981 (0.968–0.993)	0.002*
Female (vs male)	1.637 (1.190–2.250)	0.002*
Chemotherapy (vs no)	1.435 (0.918–2.242)	0.113
Thyrotoxicosis (vs no)	0.665 (0.478–0.926)	0.016*
Thyroid VS55 (per cm³ increase)	0.905 (0.871–0.940)	0.000*
The VS60 Model
Age (per year increase)	0.982 (0.970–0.994)	0.004*
Female (vs male)	1.652 (1.203–2.268)	0.002*
Chemotherapy (vs no)	1.562 (1.002–2.435)	0.049
Thyrotoxicosis (vs no)	0.677 (0.485–0.944)	0.021*
Thyroid VS60 (per cm³ increase)	0.921 (0.891–0.951)	0.000*

*Means p < 0.05

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