Variability of α/β ratios for prostate cancer with the fractionation schedule: caution against using the linear-quadratic model for hypofractionated radiotherapy

Table 5 Parameters estimated with 95% CIs in different regimens of radiotherapy

	K			α (Gy⁻¹)			α/β (Gy)
	Estimate	95% CI	P	Estimate	95% CI	P	Estimate	95% CI BCa95% CI^*	P
Conventional fractionation	5.35	4.61–6.08	< 0.001	0.043	0.029–0.056	< 0.001	1.78	1.59–1.98	< 0.001
Conventional fractionation	5.35	4.61–6.08	< 0.001	0.043	0.029–0.056	< 0.001	1.78	1.62–1.97	< 0.001
Moderate hypofractionation	1.15	0.21–2.09	0.017	0.026	0.016–0.036	< 0.001	3.46	3.27–3.65	< 0.001
Moderate hypofractionation	1.15	0.21–2.09	0.017	0.026	0.016–0.036	< 0.001	3.46	3.30–3.66	< 0.001
SBRT	1.67	− 4.80–8.15	0.61	0.042	− 0.27–0.36	0.79	4.24	4.10–4.39	< 0.001
SBRT	1.67	− 4.80–8.15	0.61	0.042	− 0.27–0.36	0.79	4.24	4.14–4.34	< 0.001

^*BCa 95% CI Bias-Corrected and accelerated intervals. We go a step further and calculate BCa intervals on the base of jackknife methods

ISSN: 1748-717X