Hypofractionated radiation leads to more rapid bleeding cessation in women with vaginal bleeding secondary to gynecologic malignancy

Table 3 Univariable and multivariable cox proportional hazards analysis of the association of listed dichotomized variables with time to bleeding cessation

Variable	Univariable analysis			Multivariable analysis
Variable	HR	95% CI	P value	HR	95% CI	P value
CFRT	3.23	1.65–6.32	0.001	3.26	1.37–7.80	0.008
Age 50+	2.17	1.11–4.22	0.022	0.74	0.28–1.96	0.543
Concurrent chemo	0.54	0.29–1.02	0.057	0.76	0.31–1.88	0.550
Non-White	0.97	0.53–1.80	0.941
AC or AP use	0.62	0.22–1.77	0.373
Non-cervical primary	1.20	0.62–2.33	0.581
Pre-menopausal	0.70	0.38–1.29	0.259
Transfusion required	1.14	0.60–2.21	0.680
Metastatic	1.15	0.60–2.20	0.669
Recurrence	3.53	1.42–8.82	0.007	1.96	0.51–7.54	0.326
Prior pelvic RT	10.50	1.17–93.9	0.035	2.06	0.16–27.00	0.582
Prior pelvic surgery	1.87	0.93–3.77	0.080	1.76	0.68–4.57	0.243
Prior systemic therapy	6.12	2.30–16.33	< 0.001	2.17	0.64–7.28	0.211
Pretreatment Hgb (continuous)	0.96	0.82–1.12	0.597

Pre-specified criteria for inclusion in a final multivariable model was p < 0.2 on univariable analysis

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