Hypofractionated radiation leads to more rapid bleeding cessation in women with vaginal bleeding secondary to gynecologic malignancy

Table 2 External beam radiation regimens utilized in patient cohort. BED10 represents the overall BED calculated with α/β = 10

RT regimen	BED₁₀ (Gy)	# (%)	MTTBC (days)
CFRT (N = 26)
1.8 Gy × 25 fx = 45 Gy	53.1	26 (100%)	16 [6–41]
HFRT (N = 17)
2.5 Gy × 16 fx = 40 Gy	50.0	4 (24%)	15.5 [5–28]
2.5 Gy × 15 fx = 37.5 Gy	46.9	4 (24%)	11 [5–17]
2.5 Gy × 10 fx = 25 Gy	31.3	1 (6%)	13
1.8 Gy × 1 fx − > 3 Gy × 3 fx − > 1.8 Gy × 20 fx = 46.8 Gy total^a	56.3	1 (6%)	1
2.2 Gy × 20 = 44 Gy	53.7	1 (6%)	6
4 Gy × 2 − > 3 Gy × 10 fx = 38 Gy total	50.2	1 (6%)	4
4 Gy × 3 fx − > 3 Gy × 4 fx = 24 Gy total	32.4	1 (6%)	1
4Gy × 5 = 20 Gy	28.0	1 (6%)	1
3.7Gy × 4 = 14.8 Gy delivered BID	20.3	1 (6%)	1
3.7 Gy × 4 = 14.8 Gy	20.3	1 (6%)	1
2.5 Gy × 3 = 7.5 Gy^b	9.4	1 (6%)	2

^aInitially planned for 1.8 Gy × 25 = 45 Gy but had worsening bleeding so switched to 3 Gy × 3 fx = 9 Gy, later followed by completion of definitive RT 36 Gy in 20 fx
^bPatient planned for 2.5 Gy × 16 fx = 40 Gy but decided to go on hospice and stopped RT
Patients with multiple fractionation schemes delivered sequentially are denoted with forward arrow sign (− >). Median time to bleeding cessation (MTTBC) is reported in days with number in brackets representing the range for fractionation schemes with multiple patients

ISSN: 1748-717X