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Table 2 Dosimetric characteristics of patients experiencing selected grade 2–3 toxicities from repeat SABR and CRT

From: An algorithm for thoracic re-irradiation using biologically effective dose: a common language on how to treat in a “no-treat zone”

Organ at risk (OAR)

Grade and number (%) of re-SABR toxicity

Composite BED3 or % corresponding to Re-SABR toxicity, mean (range)

Grade and number (%) of re-CRT toxicity

Composite BED3 or % corresponding to toxicity, mean (range)

Brachial plexus

    

Dmax

D0.2 cc

Grade 2 brachial plexopathy, n = 1 (7%)

144 Gy

123 Gy

-

-

Chest wall

    

Dmax

D30cc

D50cc

Grade 2 rib fracture, n = 3 (21%)

370 Gy (288–432)

225 Gy (166–339)

187 (122–308)

Grade 2 rib fracture, n = 2 (8%)

403 Gy (353–452)

209 Gy (175–243)

139 (100–177 Gy)

Chest wall

    

Dmax

D30cc

D50cc

Grade 2 chest wall pain, n = 1 (7%)

411 Gy

107 Gy

83 Gy

Grade 2 chest wall pain, n = 3 (13%)

386 Gy (353–452)

243 Gy (175–310)

177 Gy (100–255)

Dmax

D30cc

D50cc

Grade 3 chest wall pain, n = 1 (7%)

390 Gy

339 Gy

308 Gy

-

-

Total Lung

    

Mean

Dmax

V5

V20

V35

Mean

Dmax

V5

V20

V35

Grade 2 pneumonitis, n = 1 (7%)

Grade 3 pneumonitis, n = 1 (7%)

15 Gy

451 Gy

32%

13%

10%

35 Gy

481 Gy

32%

23%

20%

Grade 2 pneumonitis, n = 1 (4%)

Grade 3 pneumonitis, n = 2 (8%)

29 Gy

382 Gy

67%

33%

25%

21 Gy (20–22)

391 (332–449)

36% (34–37)

24% (23–25)

19% (18–19)

Total lung

    

Mean

Dmax

V5

V20

V35

Grade 2 dyspnea, n = 3 (21%)

24 Gy (11–33)

487 Gy (377–622)

49% (23–77)

27% (11–45)

17% (7–25)

Grade 2 dyspnea, n = 2 (8%)

33 Gy (32–34)

444 Gy (362–526)

62% (55–68)

36% (30–41)

28% (24–31)

Mean

Dmax

V5

V20

V35

Grade 3 dyspnea, n = 1 (7%)

35 Gy

481 Gy

32%

23%

20%

Grade 3 dyspnea, n = 2 (8%)

26 Gy (22–29)

416 Gy (382–449)

52% (37–67)

28% (23–33)

22% (19–25)