Glioblastoma radiotherapy using Intensity modulated Radiotherapy (IMRT) or proton Radiotherapy—GRIPS Trial (Glioblastoma Radiotherapy via IMRT or Proton BeamS): a study protocol for a multicenter, prospective, open-label, randomized, two-arm, phase III study

Table 1 Intervention and assessment schedule for the GRIPS trial

	Inclusion examination	RT	Examination after RT	V1: 4 weeks after RT	V2: month 4	V3: month 7	V4: month 10	V5: month 13	V6: month 16	V7: month 19	V8: month 22	V9: month 25
Screening	x
CRF form	x		x	x	x	x	x	x	x	x	x	x
QLQ-C30 und QLQ-BN20	x		x		x			x
Hopkins Verbal Learning Test- Revised	x		x		x			x
Symptoms/ Toxicity according to CTCAE	x		x	x	x	x	x	x	x	x	x	x
MRI	x^a			x	x	x	x	x	x	x	x	x
RT		x
Additional scientific program	x		x	x	x

RT = radiotherapy
Screening: includes check of inclusion and exclusion criteria, taking of medical history including surgical and pathological report, medical examination and randomization
^a MRI less than 4 weeks old, if older at time of inclusion, a new MRI for planning is mandatory

ISSN: 1748-717X