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Table 3 The adjusted risk of cerebrovascular mortality by local treatment groups

From: Increased risk of cerebrovascular mortality in head and neck cancer survivors aged ≥ 65 years treated with definitive radiotherapy: a population-based cohort study

Variables

HR

95% CI

P

Entire cohort

 Surgery alone

1

  

 RT alone

1.703

1.398–2.075

 < 0.001

 Surgery plus RT

1.106

0.923–1.325

0.274

Aged 65–69 years

   

 Surgery alone

1

  

 RT alone

2.253

1.418–3.580

0.001

 Surgery plus RT

1.352

0.862–2.121

0.188

Aged 70–74 years

 Surgery alone

1

  

 RT alone

1.591

1.161–2.179

0.004

 Surgery plus RT

1.056

0.745–1.497

0.760

Aged ≥ 74 years

 Surgery alone

1

  

 RT alone

1.756

1.354–2.278

 < 0.001

 Surgery plus RT

1.179

0.938–1.481

0.158

Male

 Surgery alone

1

  

 RT alone

1.558

1.221–1.987

 < 0.001

 Surgery plus RT

1.098

0.871–1.384

0.429

Female

 Surgery alone

1

  

 RT alone

2.344

1.759–3.123

 < 0.001

 Surgery plus RT

1.104

0.844–1.445

0.471

Oral cavity, oropharynx, nasopharynx, and hypopharynx

 Surgery alone

1

  

 RT alone

2.519

1.881–3.374

 < 0.001

 Surgery plus RT

1.200

0.909–1.583

0.198

Other tumor sites

 Surgery alone

1

  

 RT alone

1.378

1.062–1.788

0.016

 Surgery plus RT

1.058

0.833–1.344

0.646

SEER localized stage

 Surgery alone

1

  

 RT alone

1.682

1.430–1.979

 < 0.001

 Surgery plus RT

1.114

0.948–1.308

0.190

SEER regional stage

   

 Surgery alone

1

  

 RT alone

2.230

1.612–3.086

 < 0.001

 Surgery plus RT

1.146

0.852–1.543

0.368

SEER distant stage

 Surgery alone

1

  

 RT alone

4.862

2.005–11.792

 < 0.001

 Surgery plus RT

1.223

0.542–2.757

0.627

Married

 Surgery alone

1

  

 RT alone

1.502

1.201–1.878

 < 0.001

 Surgery plus RT

0.982

0.783–1.231

0.875

Unmarried

 Surgery alone

1

  

 RT alone

1.879

1.414–2.496

 < 0.001

 Surgery plus RT

1.165

0.901–1.506

0.243

No chemotherapy

 Surgery alone

1

  

 RT alone

1.682

1.410–2.008

 < 0.001

 Surgery plus RT

1.159

0.978–1.374

0.089

Chemotherapy

 Surgery plus RT

1

  

 Surgery alone

2.230

0.903–5.957

0.080

 RT alone

1.779

1.210–2.615

0.003

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Radiation Oncology

ISSN: 1748-717X

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