Patterns of nodal spread in stage III NSCLC: importance of EBUS-TBNA and 18F-FDG PET/CT for radiotherapy target volume definition

Table 4 EBUS-positivity in echelon-3: Respective odds ratios (OR) according to prognostic factors from univariable and multivariable analysis

Significant prognostic factors	EBUS positivity in echelon 3
	Univariable analysis		Multivariable analysis
	OR (95%-CI)	p-value, χ²-test	OR (95%-CI)	p-value, χ²-test
PET-positivity vs. negativity in echelon-3	12.7 (3.5–46.4)	0.0001	12.1 (3.2–46.5)	0.0003
EBUS-positivity vs. negativity in echelon-2	5.9 (1.3–26.7)	0.021	6.7 (1.31–31.2)	0.022
Laterality (left-sided tumors compared with right-sided)	2.8 (1.01–7.9)	0.049	4.0 (1.24–13.2)	0.020

The respective odds ratios for EBUS-positivity in echelon-3 according to the prognostic factors from univariable and multivariable logistic regression analysis were: (i) OR = 12.7 (95%-CI: 3.5–46.4) (p = 0.0001, χ²-test) and OR = 12.1 (95%-CI: 3.2–46.5) (p = 0.0003, χ²-test) in dependence on PET-positivity vs. negativity in echelon-3, (ii) OR = 5.9 (95 CI: 1.3–26.7) (p = 0.021, χ²-test) and OR = 6.7 (95%-CI: 1.31–31.2) (p = 0.022, χ²-test) in dependence on EBUS-positivity vs. negativity in echelon-2, as well as (iii) OR = 2.8 (95%-CI: 1.01–7.9) (p = 0.049, χ²-test) and OR = 4.0 (95%-CI: 1.24–13.2) (p = 0.020, χ²-test) for left-sided tumors compared with right-sided

ISSN: 1748-717X